| 释义 |
- See also
- References
- Further reading
- External links
{{Infobox_gene}}P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.[3]
}}See alsoReferences1. ^{{cite journal | vauthors = Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF | title = Molecular and functional characterization of human P2X(2) receptors | journal = Mol Pharmacol | volume = 56 | issue = 6 | pages = 1171–81 |date=Dec 1999 | pmid = 10570044 | pmc = | doi = }}
2. ^{{cite journal | vauthors = Brake AJ, Wagenbach MJ, Julius D | title = New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor | journal = Nature | volume = 371 | issue = 6497 | pages = 519–23 |date=Oct 1994 | pmid = 7523952 | pmc = | doi = 10.1038/371519a0 }}
3. ^1 {{cite web | title = Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22953| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=North RA |title=Molecular physiology of P2X receptors |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013–67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
- {{cite journal |vauthors=Barrera NP, Ormond SJ, Henderson RM, etal |title=Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10759–65 |year= 2005 |pmid= 15657042 |doi= 10.1074/jbc.M412265200 }}
- {{cite journal | vauthors=Mason HS, Bourke S, Kemp PJ |title=Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1525–35 |year= 2005 |pmid= 15331767 |doi= 10.1124/mol.104.000851 }}
- {{cite journal |vauthors=Aschrafi A, Sadtler S, Niculescu C, etal |title=Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes |journal=J. Mol. Biol. |volume=342 |issue= 1 |pages= 333–43 |year= 2004 |pmid= 15313628 |doi= 10.1016/j.jmb.2004.06.092 }}
- {{cite journal |vauthors=Boué-Grabot E, Emerit MB, Toulmé E, etal |title=Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 6967–75 |year= 2004 |pmid= 14660627 |doi= 10.1074/jbc.M307772200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Järlebark LE, Housley GD, Raybould NP, etal |title=ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea |journal=NeuroReport |volume=13 |issue= 15 |pages= 1979–84 |year= 2003 |pmid= 12395104 |doi=10.1097/00001756-200210280-00030 }}
- {{cite journal |vauthors=Khakh BS, Zhou X, Sydes J, etal |title=State-dependent cross-inhibition between transmitter-gated cation channels |journal=Nature |volume=406 |issue= 6794 |pages= 405–10 |year= 2000 |pmid= 10935636 |doi= 10.1038/35019066 }}
- {{cite journal |vauthors=Brändle U, Spielmanns P, Osteroth R, etal |title=Desensitization of the P2X(2) receptor controlled by alternative splicing |journal=FEBS Lett. |volume=404 |issue= 2–3 |pages= 294–8 |year= 1997 |pmid= 9119082 |doi=10.1016/S0014-5793(97)00128-2 }}
- {{cite journal |vauthors=Lewis C, Neidhart S, Holy C, etal |title=Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons |journal=Nature |volume=377 |issue= 6548 |pages= 432–5 |year= 1995 |pmid= 7566120 |doi= 10.1038/377432a0 }}
{{refend}} External links - {{MeshName|P2RX2+protein,+human}}
{{NLM content}}{{Ligand-gated ion channels}}{{Purinergics}}{{membrane-protein-stub}} 1 : Ion channels |