| 释义 |
- See also
- References
- Further reading
- External links
{{Infobox_gene}}P2X purinoceptor 3 is a protein that in humans is encoded by the P2RX3 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes, platelet aggregation, macrophage activation, apoptosis and neuronal–glial interactions. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.[2]
}}See also- P2X purinoreceptor
- Purinergic receptor
- Ligand-gated ion channel
- Nociceptor
References1. ^{{cite journal |vauthors=Garcia-Guzman M, Stuhmer W, Soto F | title = Molecular characterization and pharmacological properties of the human P2X3 purinoceptor | journal = Brain Res Mol Brain Res | volume = 47 | issue = 1–2 | pages = 59–66 |date=Sep 1997 | pmid = 9221902 | pmc = | doi =10.1016/S0169-328X(97)00036-3 }}
2. ^1 {{cite web | title = Entrez Gene: P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5024| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=North RA |title=Molecular physiology of P2X receptors |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013–67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
- {{cite journal | author=Jarvis MF |title=Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain |journal=Expert Opin. Ther. Targets |volume=7 |issue= 4 |pages= 513–22 |year= 2005 |pmid= 12885270 |doi= 10.1517/14728222.7.4.513 }}
- {{cite journal |vauthors=Kennedy C, Leff P |title=Painful connection for ATP |journal=Nature |volume=377 |issue= 6548 |pages= 385–6 |year= 1995 |pmid= 7566110 |doi= 10.1038/377385a0 }}
- {{cite journal | author=Lewis C |title=Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons |journal=Nature |volume=377 |issue= 6548 |pages= 432–5 |year= 1995 |pmid= 7566120 |doi= 10.1038/377432a0 |name-list-format=vanc| author2=Neidhart S | author3=Holy C | display-authors=3 | last4=North | first4=R. A. | last5=Buell | first5=G. | last6=Surprenant | first6=A. }}
- {{cite journal | author=Garcia-Guzman M |title=Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue |journal=Mol. Pharmacol. |volume=51 |issue= 1 |pages= 109–18 |year= 1997 |pmid= 9016352 |doi= |name-list-format=vanc| author2=Soto F | author3=Gomez-Hernandez JM | display-authors=3 | last4=Lund | first4=PE | last5=Stühmer | first5=W }}
- {{cite journal |vauthors=Cook SP, McCleskey EW |title=ATP, pain and a full bladder |journal=Nature |volume=407 |issue= 6807 |pages= 951–2 |year= 2000 |pmid= 11069162 |doi= 10.1038/35039648 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
- {{cite journal | author=Renton T |title=Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp |journal=Journal of Orofacial Pain |volume=17 |issue= 3 |pages= 245–50 |year= 2003 |pmid= 14520770 |doi= |name-list-format=vanc| author2=Yiangou Y | author3=Baecker PA | display-authors=3 | last4=Ford | first4=AP | last5=Anand | first5=P }}
- {{cite journal |vauthors=Mason HS, Bourke S, Kemp PJ |title=Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1525–35 |year= 2005 |pmid= 15331767 |doi= 10.1124/mol.104.000851 }}
- {{cite journal | author=Fabbretti E |title=Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53109–15 |year= 2005 |pmid= 15475563 |doi= 10.1074/jbc.M409772200 |name-list-format=vanc| author2=Sokolova E | author3=Masten L | display-authors=3 | last4=d'Arco | first4=M. | last5=Fabbro | first5=A. | last6=Nistri | first6=A. | last7=Giniatullin | first7=R. }}
- {{cite journal |vauthors=Brown DA, Yule DI |title=Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation |journal=Biochim. Biophys. Acta |volume=1773 |issue= 2 |pages= 166–75 |year= 2007 |pmid= 17052768 |doi= 10.1016/j.bbamcr.2006.09.020 | pmc=1861828 }}
{{refend}} External links - {{MeshName|P2RX3+protein,+human}}
{{NLM content}}{{Ligand-gated ion channels}}{{Purinergics}}{{membrane-protein-stub}} 1 : Ion channels |