P59, P-59 or P.59 may refer to:

• Bell XP-59, a proposed American twin-boom fighter unrelated to the later P-59 jet
• Bell P-59 Airacomet, an American jet fighter aircraft
• {{HMS|Untiring|P59}}, a Second World War Royal Navy submarine
• P.59 Partenavia Jolly, a training aircraft, one only built in 1960
• P59, a Latvian State Regional Road - see List of National Roads in Latvia
• p59, an alias of GRASP55, golgi reassembly stacking protein 2

• The Half-Breed's Way
• The Half Fast Marching Club
• The Half Fast Walking Club
• The Half-Hour News Hour
• The half hour newshour
• The Half Hour News Hour
• The Half-King
• The Half King
• The Half Life of Timofey Berezin
• The Halfling's Gem
• The Half-Naked Truth
• The Half Note Club
• 'The Half of It, Dearie' Blues
• The Half-Way Girl
• The Halfway House
• The Halifax
• The Halifax Three
• The Hallam Company
• The Hallamshire Battalion
• The Hall China Company
• The Halley Academy
• The Halley Project
• The Hallmark Channel
• The Hallmark Channel (Australia)
• The Hall of Mosses