| 词条 | Logopenic progressive aphasia |
| 释义 |
Although patients with the logopenic variant of PPA are still able to produce speech, their speech rate may be significantly slowed down due to word retrieval difficulty.[4] Over time, they may experience the inability to retain lengthy information, causing problems with understanding complex verbal information.[5] Some additional behavioral features include irritability, anxiety and agitation.[3] Compared to other forms of primary progressive aphasia, the logopenic variant has been found to be associated with cognitive and behavioral characteristics. Studies have shown that patients with the logopenic variant perform significantly worse on tests of calculation than other primary progressive aphasia patients. Several logopenic variant patients, especially those with Alzheimer’s disease pathology, have also been found to perform poorly on memory tasks.[3] Logopenic progressive aphasia is caused by damage to segregated brain regions, specifically the inferior parietal lobe and superior temporal regions. Difficulties in naming are produced from the thinning of the inferior parietal lobe. Damage to the dorsal pathways creates language deficiency in patients that is characteristic of logopenic progressive aphasia.[2] See also
References1. ^{{cite journal |vauthors=Harciarek M, Kertesz A |title=Primary progressive aphasias and their contribution to the contemporary knowledge about the brain-language relationship |journal=Neuropsychol Rev |volume=21 |issue=3 |pages=271–87 |date=September 2011 |pmid=21809067 |pmc=3158975 |doi=10.1007/s11065-011-9175-9 |url=}} 2. ^1 {{cite journal |vauthors=Leyton CE, Piguet O, Savage S, Burrell J, Hodges JR |title=The neural basis of logopenic progressive aphasia |journal=J. Alzheimers Dis. |volume=32 |issue=4 |pages=1051–9 |year=2012 |pmid=22890099 |doi=10.3233/JAD-2012-121042 |url=}} 3. ^1 2 {{cite journal |vauthors=Henry ML, Gorno-Tempini ML |title=The logopenic variant of primary progressive aphasia |journal=Curr. Opin. Neurol. |volume=23 |issue=6 |pages=633–7 |date=December 2010 |pmid=20852419 |pmc=3201824 |doi=10.1097/WCO.0b013e32833fb93e |url=}} 4. ^1 {{cite journal |vauthors=Gorno-Tempini ML, Hillis AE, Weintraub S, etal |title=Classification of primary progressive aphasia and its variants |journal=Neurology |volume=76 |issue=11 |pages=1006–14 |date=March 2011 |pmid=21325651 |pmc=3059138 |doi=10.1212/WNL.0b013e31821103e6 |url=}} 5. ^UCSF Memory and Aging Center. (2011, February 22). SF: The Regents of the University of California. Retrieved December 5, 2011 from http://memory.ucsf.edu/education/diseases/ppa Further reading
4 : Aphasias|Cognitive disorders|Dementia|Alzheimer's disease |
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