| 释义 |
- Selective Ligands Agonists Antagonists
- See also
- References
- External links
- Further reading
{{Infobox_gene}}Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene.[1][2]Selective LigandsAgonists- Pancreatic polypeptide
- Neuropeptide Y (endogenous agonist, non subtype selective)
- Peptide YY
- GR-231,118 (mixed NPY1 antagonist / NPY4 agonist, CAS# 158859-98-4)
Antagonists See also References 1. ^{{cite journal | vauthors = Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA | title = Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY | journal = Genomics | volume = 46 | issue = 2 | pages = 287–90 | date = Dec 1997 | pmid = 9417917 | pmc = | doi = 10.1006/geno.1997.5024 }}
2. ^{{cite web | title = Entrez Gene: PPYR1 pancreatic polypeptide receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5540| accessdate = }}
3. ^{{cite journal | vauthors = Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A | title = Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence | journal = Journal of Receptor and Signal Transduction Research | volume = 27 | issue = 4 | pages = 217–33 | year = 2007 | pmid = 17885919 | doi = 10.1080/10799890701505206 }}
External links - {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2370 | title = Neuropeptide Y Receptors: Y4 | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
Further reading {{refbegin |33em}}- {{cite journal | vauthors = Keire DA, Bowers CW, Solomon TE, Reeve JR | title = Structure and receptor binding of PYY analogs | journal = Peptides | volume = 23 | issue = 2 | pages = 305–21 | date = Feb 2002 | pmid = 11825645 | doi = 10.1016/S0196-9781(01)00602-7 }}
- {{cite journal | vauthors = Balasubramaniam A | title = Clinical potentials of neuropeptide Y family of hormones | journal = American Journal of Surgery | volume = 183 | issue = 4 | pages = 430–4 | date = Apr 2002 | pmid = 11975932 | doi = 10.1016/S0002-9610(02)00803-6 }}
- {{cite journal | vauthors = Parker E, Van Heek M, Stamford A | title = Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status | journal = European Journal of Pharmacology | volume = 440 | issue = 2-3 | pages = 173–87 | date = Apr 2002 | pmid = 12007534 | doi = 10.1016/S0014-2999(02)01427-9 }}
- {{cite journal | vauthors = Benaim G, Villalobo A | title = Phosphorylation of calmodulin. Functional implications | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 15 | pages = 3619–31 | date = Aug 2002 | pmid = 12153558 | doi = 10.1046/j.1432-1033.2002.03038.x }}
- {{cite journal | vauthors = Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D | title = Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY | journal = The Journal of Biological Chemistry | volume = 270 | issue = 49 | pages = 29123–8 | date = Dec 1995 | pmid = 7493937 | doi = 10.1074/jbc.270.49.29123 }}
- {{cite journal | vauthors = Bard JA, Walker MW, Branchek TA, Weinshank RL | title = Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY | journal = The Journal of Biological Chemistry | volume = 270 | issue = 45 | pages = 26762–5 | date = Nov 1995 | pmid = 7592911 | doi = 10.1074/jbc.270.45.26762 }}
- {{cite journal | vauthors = Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W | title = Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 10 | pages = 4661–5 | date = May 1996 | pmid = 8643460 | pmc = 39335 | doi = 10.1073/pnas.93.10.4661 }}
- {{cite journal | vauthors = Kawabe T, Muslin AJ, Korsmeyer SJ | title = HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint | journal = Nature | volume = 385 | issue = 6615 | pages = 454–8 | date = Jan 1997 | pmid = 9009195 | doi = 10.1038/385454a0 }}
- {{cite journal | vauthors = Darby K, Eyre HJ, Lapsys N, Copeland NG, Gilbert DJ, Couzens M, Antonova O, Sutherland GR, Jenkins NA, Herzog H | title = Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14 | journal = Genomics | volume = 46 | issue = 3 | pages = 513–5 | date = Dec 1997 | pmid = 9441761 | doi = 10.1006/geno.1997.5071 }}
- {{cite journal | vauthors = Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P | title = Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 | journal = Biochemistry | volume = 38 | issue = 14 | pages = 4365–73 | date = Apr 1999 | pmid = 10194355 | doi = 10.1021/bi982900m }}
- {{cite journal | vauthors = Smith FD, Oxford GS, Milgram SL | title = Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein | journal = The Journal of Biological Chemistry | volume = 274 | issue = 28 | pages = 19894–900 | date = Jul 1999 | pmid = 10391935 | doi = 10.1074/jbc.274.28.19894 }}
- {{cite journal | vauthors = Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR | title = PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts | journal = Cell | volume = 101 | issue = 4 | pages = 365–76 | date = May 2000 | pmid = 10830164 | doi = 10.1016/S0092-8674(00)80847-8 }}
- {{cite journal | vauthors = Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S | title = Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 | journal = Molecular and Cellular Biology | volume = 21 | issue = 20 | pages = 6841–50 | date = Oct 2001 | pmid = 11564868 | pmc = 99861 | doi = 10.1128/MCB.21.20.6841-6850.2001 }}
- {{cite journal | vauthors = Cavadas C, Silva AP, Mosimann F, Cotrim MD, Ribeiro CA, Brunner HR, Grouzmann E | title = NPY regulates catecholamine secretion from human adrenal chromaffin cells | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 86 | issue = 12 | pages = 5956–63 | date = Dec 2001 | pmid = 11739470 | doi = 10.1210/jc.86.12.5956 }}
- {{cite journal | vauthors = Cox HM, Tough IR | title = Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa | journal = British Journal of Pharmacology | volume = 135 | issue = 6 | pages = 1505–12 | date = Mar 2002 | pmid = 11906964 | pmc = 1573267 | doi = 10.1038/sj.bjp.0704604 }}
- {{cite journal | vauthors = Wu DY, Tkachuck DC, Roberson RS, Schubach WH | title = The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27706–15 | date = Aug 2002 | pmid = 12016208 | doi = 10.1074/jbc.M200955200 }}
{{refend}}{{transmembranereceptor-stub}}{{NLM content}}{{G protein-coupled receptors|g1}}{{Neuropeptidergics}} 1 : G protein-coupled receptors |