“Pantetheine-phosphate adenylyltransferase”的意思、由来-开放百科全书

词条

Pantetheine-phosphate adenylyltransferase

释义

Structural studies
References

{{enzyme
| Name = pantetheine-phosphate adenylyltransferase
| EC_number = 2.7.7.3
| CAS_number = 9026-99-7
| IUBMB_EC_number = 2/7/7/3
| GO_code = 0004595
| image = 1vlh.png
| width =
| caption = Phosphopantetheine adenylyltransferase from Thermotoga maritima. 4'-Phosphopantetheine shown as spheres. PDB {{PDBe|1vlh}}
}}

In enzymology, a pantetheine-phosphate adenylyltransferase ({{EC number|2.7.7.3}}) is an enzyme that catalyzes the chemical reaction

ATP + 4'-Phosphopantetheine diphosphate + 3'-dephospho-CoA

Thus, the two substrates of this enzyme are ATP and 4'-Phosphopantetheine, whereas its two products are diphosphate and 3'-dephospho-CoA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1B6T}}, {{PDB link|1GN8}}, {{PDB link|1H1T}}, {{PDB link|1O6B}}, {{PDB link|1OD6}}, {{PDB link|1QJC}}, {{PDB link|1TFU}}, and {{PDB link|1VLH}}.

References

{{cite journal |vauthors=HOAGLAND MB, NOVELLI GD | date = 1954 | title = Biosynthesis of coenzyme A from phospho-pantetheine and of pantetheine from pantothenate | journal = J. Biol. Chem. | volume = 207 | pages = 767–73 | pmid = 13163064 | issue = 2 }}
{{cite journal | author = NOVELLI GD | date = 1953 | title = Enzymatic synthesis and structure of CoA | journal = Fed. Proc. | volume = 12 | pages = 675–81 | pmid = 13107738 | issue = 3 }}
{{cite journal |vauthors=Martin DP, Drueckhammer DG | date = 1993 | title = Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase | journal = Biochem. Biophys. Res. Commun. | volume = 192 | pages = 1155–61 | pmid = 8389542 | doi = 10.1006/bbrc.1993.1537 | issue = 3 }}
{{cite journal |vauthors=Geerlof A, Lewendon A, Shaw WV | date = 1999 | title = Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli | journal = J. Biol. Chem. | volume = 274 | pages = 27105–11 | pmid = 10480925 | doi = 10.1074/jbc.274.38.27105 | issue = 38 }}
{{cite journal |vauthors=Izard T, Geerlof A, Lewendon A, Barker JJ | date = | title = Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli | journal = Acta Crystallogr. D | volume = 55 | pages = 1226–8 | pmid = 10329792 | doi = 10.1107/S0907444999004394 | issue = Pt 6 }}

2 : EC 2.7.7|Enzymes of known structure

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