“PARP4”的意思、由来-开放百科全书

　

词条

PARP4

释义

Interactions
References
Further reading

{{Infobox_gene}}Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.^[1]^[2]

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.^[2]

Interactions

PARP4 has been shown to interact with Major vault protein.^[3]^[4]

References

1. ^{{cite journal |vauthors=Still IH, Vince P, Cowell JK | title = Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein | journal = Genomics | volume = 62 | issue = 3 | pages = 533–6 |date=Mar 2000 | pmid = 10644454 | pmc = | doi = 10.1006/geno.1999.6024 }}
2. ^¹{{cite web | title = Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=143| accessdate = }}
3. ^{{cite journal |last=van Zon |first=Arend |authorlink= |author2=Mossink Marieke H |author3=Schoester Martijn |author4=Scheffer George L |author5=Scheper Rik J |author6=Sonneveld Pieter |author7=Wiemer Erik A C |date=Mar 2002 |title=Structural domains of vault proteins: a role for the coiled coil domain in vault assembly |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue=3 |pages=535–41 | issn = 0006-291X| pmid = 11855821 |doi = 10.1006/bbrc.2002.6472 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
4. ^{{cite journal |doi=10.1083/jcb.146.5.917 |last=Kickhoefer |first=V A |authorlink= |author2=Siva A C |author3=Kedersha N L |author4=Inman E M |author5=Ruland C |author6=Streuli M |author7=Rome L H |date=Sep 1999 |title=The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase |journal=J. Cell Biol. |volume=146 |issue=5 |pages=917–28 | issn = 0021-9525| pmid = 10477748 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2169495 }}

Further reading

{{refbegin | 2}}

{{cite journal |vauthors=Jean L, Risler JL, Nagase T, etal |title=The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair? |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 6–8 |year= 1999 |pmid= 10100603 |doi=10.1016/S0014-5793(99)00173-8 }}
{{cite journal |vauthors=Soldani C, Scovassi AI |title=Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. |journal=Apoptosis |volume=7 |issue= 4 |pages= 321–8 |year= 2003 |pmid= 12101391 |doi=10.1023/A:1016119328968 }}
{{cite journal |vauthors=Bouchard VJ, Rouleau M, Poirier GG |title=PARP-1, a determinant of cell survival in response to DNA damage. |journal=Exp. Hematol. |volume=31 |issue= 6 |pages= 446–54 |year= 2003 |pmid= 12829019 |doi=10.1016/S0301-472X(03)00083-3 }}
{{cite journal |vauthors=Soares MB, Bonaldo MF, Jelene P, etal |title=Construction and characterization of a normalized cDNA library. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 20 |pages= 9228–32 |year= 1994 |pmid= 7937745 |doi=10.1073/pnas.91.20.9228 | pmc=44785 |bibcode=1994PNAS...91.9228S }}
{{cite journal |vauthors=Nagase T, Seki N, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17–24 |year= 1996 |pmid= 8724849 |doi=10.1093/dnares/3.1.17 }}
{{cite journal |vauthors=Kickhoefer VA, Siva AC, Kedersha NL, etal |title=The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 917–28 |year= 1999 |pmid= 10477748 |doi=10.1083/jcb.146.5.917 | pmc=2169495 }}
{{cite journal |vauthors=Kickhoefer VA, Stephen AG, Harrington L, etal |title=Vaults and telomerase share a common subunit, TEP1. |journal=J. Biol. Chem. |volume=274 |issue= 46 |pages= 32712–7 |year= 2000 |pmid= 10551828 |doi=10.1074/jbc.274.46.32712 }}
{{cite journal |vauthors=Siva AC, Raval-Fernandes S, Stephen AG, etal |title=Up-regulation of vaults may be necessary but not sufficient for multidrug resistance. |journal=Int. J. Cancer |volume=92 |issue= 2 |pages= 195–202 |year= 2001 |pmid= 11291045 |doi=10.1002/1097-0215(200102)9999:9999<::AID-IJC1168>3.0.CO;2-7 }}
{{cite journal |vauthors=van Zon A, Mossink MH, Schoester M, etal |title=Multiple human vault RNAs. Expression and association with the vault complex. |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37715–21 |year= 2001 |pmid= 11479319 |doi= 10.1074/jbc.M106055200 }}
{{cite journal |vauthors=van Zon A, Mossink MH, Schoester M, etal |title=Structural domains of vault proteins: a role for the coiled coil domain in vault assembly. |journal=Biochem. Biophys. Res. Commun. |volume=291 |issue= 3 |pages= 535–41 |year= 2002 |pmid= 11855821 |doi= 10.1006/bbrc.2002.6472 }}
{{cite journal |vauthors=Mazzon E, Dugo L, Li JH, etal |title=GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat. |journal=Biochem. Pharmacol. |volume=64 |issue= 2 |pages= 327–37 |year= 2002 |pmid= 12123754 |doi=10.1016/S0006-2952(02)01075-4 }}
{{cite journal |vauthors=Liu TJ, Lin SY, Chau YP |title=Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. |journal=Toxicol. Appl. Pharmacol. |volume=182 |issue= 2 |pages= 116–25 |year= 2002 |pmid= 12140175 |doi=10.1006/taap.2002.9438 }}
{{cite journal |vauthors=Nie Z, Phenix BN, Lum JJ, etal |title=HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation. |journal=Cell Death Differ. |volume=9 |issue= 11 |pages= 1172–84 |year= 2003 |pmid= 12404116 |doi= 10.1038/sj.cdd.4401094 }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
{{cite journal |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |bibcode=2004Natur.428..522D }}
{{cite journal |vauthors=Liu Y, Snow BE, Kickhoefer VA, etal |title=Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 12 |pages= 5314–23 |year= 2004 |pmid= 15169895 |doi= 10.1128/MCB.24.12.5314-5323.2004 | pmc=419898 }}

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