| 词条 | PASTA domain |
| 释义 |
| Symbol = PASTA | Name = PASTA domain | image = Pasta domain from 3m9g.png | width = | caption = Cartoon representation of PASTA domain from Staphylococcus aureus. PDB entry {{PDBe|3m9g}} | Pfam = PF03793 | InterPro = IPR005543 | SMART = PASTA | PROSITE = PDOC51178 | SCOP = 1rp5 | TCDB = | OPM family = | OPM protein = | CDD= cd06573 | PDB = {{PDB2|1k25}}A:694-750, {{PDB2|1qme}}A:694-750, {{PDB2|1rp5}}B:694-750, {{PDB2|1qmf}}A:694-750, {{PDB2|1pyy}}A:694-750 }} The PASTA domain is a small protein domain that can bind to beta-lactam rings found in antibiotics.[1] The domain was initially discovered in 2002 by Yeats and colleagues as a region of sequence similarity found in penicillin binding proteins and PknB-like kinases found in some bacteria. The name is an acronym derived from PBP and Serine/Threonine kinase Associated domain. StructureThe PASTA domain adopts a structure composed of an alpha-helix followed by three beta strands. Recent structural studies show that the extracellular region of PknB that is composed of four PASTA domains shows a linear arrangement of the domains.[2] Species distributionPASTA domains are found in a variety of bacterial species including gram-positive firmicutes and actinobacteria. References1. ^{{cite journal |vauthors=Yeats C, Finn RD, Bateman A |title=The PASTA domain: a beta-lactam-binding domain |journal=Trends Biochem. Sci. |volume=27 |issue=9 |pages=438 |date=September 2002 |pmid=12217513 |doi= 10.1016/s0968-0004(02)02164-3|url=}} 2. ^{{cite journal |vauthors=Barthe P, Mukamolova GV, Roumestand C, Cohen-Gonsaud M |title=The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation |journal=Structure |volume=18 |issue=5 |pages=606–15 |date=May 2010 |pmid=20462494 |doi=10.1016/j.str.2010.02.013 |url=}} 1 : Protein domains |
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