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词条 Lorenzo's oil
释义

  1. Treatment costs

  2. Proposed mechanism of action

  3. Effectiveness

  4. Side effects

  5. Current state

  6. References

  7. External links

{{For|the film|Lorenzo's Oil}}Lorenzo’s oil is 4 parts glycerol trioleate and 1 part glycerol trierucate, which are the triacylglycerol forms of oleic acid and erucic acid[1] and are prepared from olive oil and rapeseed oil.[2]

It is used in the investigational treatment of asymptomatic patients with adrenoleukodystrophy (ALD). The oil was formulated by Augusto and Michaela Odone after their son Lorenzo was diagnosed with the disease in 1984, at the age of five, with the actual production initially developed by retired British scientist Don Suddaby (formerly of Croda International).[3] Suddaby and his colleague, Keith Coupland, received U.S. Patent No. 5,331,009[4] for the oil. The royalties received by Augusto were paid to The Myelin Project which he and Michaela founded to further research treatments for ALD and similar disorders.{{citation needed|date=September 2013}} The Odones and their invention obtained widespread publicity in 1992 because of the film Lorenzo’s Oil.

Lorenzo Odone died on May 30, 2008, at the age of 30, after suffering from aspiration pneumonia, caused by food getting stuck in his lungs.[5][6]

Treatment costs

Lorenzo's oil costs approximately $400 USD for a month's treatment.[7]

Proposed mechanism of action

The mixture of fatty acids purportedly reduces the levels of very long chain fatty acids (VLCFAs), which are elevated in ALD. It does so by competitively inhibiting the enzyme that forms VLCFAs.[8]

Effectiveness

{{main|Adrenoleukodystrophy#Treatment}}

Lorenzo's oil, in combination with a diet low in VLCFA, has been investigated for its possible effects on the progression of ALD. Clinical results have been mixed and the use of Lorenzo's oil has been controversial due to uncertainties regarding its clinical efficacy and the clinical indications for its use.[9]

Hugo Moser played a prominent role in both the treatment of Lorenzo Odone and the scientific evaluation of Lorenzo's oil. In 2005, Moser published a controlled study concluding that Lorenzo's oil does not alter the course of the illness in symptomatic patients, but asymptomatic patients had a reduced risk of developing ALD while on the dietary therapy.[10] Moser appraised Lorenzo's oil again in a 2007 report.[11]

Moser's findings, that Lorenzo's oil did not help symptomatic ALD patients, are consistent with prior studies published in 2003[12] and 1999.[9][13]

A study by Poulos published in 1994 found that Lorenzo's oil is of limited value in correcting the accumulation of saturated VLCFAs in the brain of patients with ALD.[14] Comparative autopsies showed that treatment enriched erucic acid in plasma and tissues, but not in the brain.[15]

Side effects

The oil has been shown to cause a lowered platelet count,[16] which can lead to thrombocytopenia and lymphopenia.[17]{{rp|646–657}}

There are no reports of toxicity from dietary consumption of erucic acid.[17][18][19]

Current state

Dietary manipulation using Lorenzo's oil has been shown to lower blood levels of very long chain fatty acids, but it is ineffective in symptomatic ALD. However, studies by Hugo Moser have found evidence that use of the oil by asymptomatic patients may slightly delay the onset of symptoms.[10]

References

1. ^http://nutrition.nutricia.com/products/lorenzos_oil
2. ^{{cite news|url=https://www.washingtonpost.com/wp-dyn/content/article/2007/01/27/AR2007012701542_pf.html |title=A Real-Life Sequel to 'Lorenzo's Oil' - washingtonpost.com |accessdate=2007-12-10 |author=Shankar Vedantam |publisher=Washington Post 2007-01-28|pages= A01|work=}}
3. ^[https://www.telegraph.co.uk/news/obituaries/2062622/Obituary-Lorenzo-Odone.html The Telegraph - Lorenzo Odone obituary]
4. ^U.S. Patent 5,331,009: Pharmaceutical compositions for treating adrenoleukodystrophy. Issued July 19, 1994.
5. ^{{Cite news |url=http://news.bbc.co.uk/2/hi/americas/7429221.stm |title=Lorenzo's Oil boy is dead at 30 |work=BBC News |date=31 May 2008 |accessdate=2008-06-02}}
6. ^{{Cite news|url=http://edition.cnn.com/2008/US/05/30/lorenzo.odone.ap/ |title=Subject of 'Lorenzo's Oil' dies at 30 |work=CNN |agency=Associated Press |date=2008-05-30 |accessdate=2008-07-12 |deadurl=yes |archiveurl=https://web.archive.org/web/20080717115741/http://edition.cnn.com/2008/US/05/30/lorenzo.odone.ap/ |archivedate=July 17, 2008 }}
7. ^{{cite web|title=Lorenzo's Oil - The Oil|url=http://www.myelin.org/lorenzosoil/lorenzosoiltheoil.html|publisher=The Myelin Project|accessdate=3 November 2012}}
8. ^http://www.myelin.org/images/scishow.swf
9. ^1 {{cite journal |vauthors=Berger J, Pujol A, Aubourg P, Forss-Petter S |title=Current and Future Pharmacological Treatment Strategies in X-Linked Adrenoleukodystrophy |journal=Brain Pathol. |volume=20 |issue=4 |pages=845–56 |date=July 2010 |pmid=20626746 |pmc=2967711 |doi=10.1111/j.1750-3639.2010.00393.x |url=}}
10. ^1 {{cite journal |vauthors=Moser HW, Raymond GV, Lu SE, Muenz LR, Moser AB, Xu J, Jones RO, Loes DJ, Melhem ER, Dubey P, Bezman L, Brereton NH, Odone A|date=July 2005|title=Follow-up of 89 asymptomatic patients with adrenoleukodystrophy treated with Lorenzo's Oil|journal=Archives of Neurology|volume=62|issue=7|pages=1073–80|pmid=16009761|doi=10.1001/archneur.62.7.1073}}
11. ^{{cite journal |vauthors=Moser HW, Moser AB, Hollandsworth K, Brereton NH, Raymond GV |title="Lorenzo's oil" therapy for X-linked adrenoleukodystrophy: rationale and current assessment of efficacy |journal=J. Mol. Neurosci. |volume=33 |issue=1 |pages=105–13 |date=September 2007 |pmid=17901554 |doi=10.1007/s12031-007-0041-4}}
12. ^{{cite journal |vauthors=Aubourg P, Adamsbaum C, Lavallard-Rousseau MC, Rocchiccioli F, Cartier N, Jambaqué I, Jakobezak C, Lemaitre A, Boureau F, Wolf C |title=A two-year trial of oleic and erucic acids ("Lorenzo's oil") as treatment for adrenomyeloneuropathy |journal=N. Engl. J. Med. |volume=329 |issue=11 |pages=745–52 |date=September 1993 |pmid=8350883 |doi=10.1056/NEJM199309093291101 |url=}}
13. ^{{cite journal |vauthors=van Geel BM, Assies J, Haverkort EB, Koelman JH, Verbeeten B, Wanders RJ, Barth PG |title=Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with "Lorenzo's oil" |journal=J. Neurol. Neurosurg. Psychiatry |volume=67 |issue=3 |pages=290–9 |date=September 1999 |pmid=10449548 |pmc=1736534 |doi= 10.1136/jnnp.67.3.290|url=http://jnnp.bmj.com/cgi/pmidlookup?view=long&pmid=10449548}}
14. ^{{cite journal |vauthors=Poulos A, Gibson R, Sharp P, Beckman K, Grattan-Smith P |title=Very long chain fatty acids in X-linked adrenoleukodystrophy brain after treatment with Lorenzo's oil |journal=Ann. Neurol. |volume=36 |issue=5 |pages=741–6 |year=1994 |pmid=7979219 |doi=10.1002/ana.410360509}}
15. ^{{cite journal |title= Brain, liver, and adipose tissue erucic and very long chain fatty acid levels in adrenoleukodystrophy patients treated with glyceryl trierucate and trioleate oils (Lorenzo's Oil) |journal=Neurochemical Research |publisher=Springer Netherlands |url=http://www.springerlink.com/content/j062517w8v068541 |volume =19 |date= Aug 1994 |doi=10.1007/BF00968719 | pages=1073–1082 |author1=Magnhild Rasmussen |author2=Ann B. Moser |author3=Janet Borel |author4=Surinder Khangoora |author5=Hugo W. Moser |issue= 8 |pmid= 7800117}}
16. ^{{cite journal |vauthors=Crowther MA, Barr RD, Kelton J, Whelan D, Greenwald M | title = Profound thrombocytopenia complicating dietary erucic acid therapy for adrenoleukodystrophy | journal = American Journal of Hematology | volume = 48 | issue = 2 | pages = 132–3 |date=February 1995 | pmid = 7847331 | doi = 10.1002/ajh.2830480217| url = }}
17. ^1 Luger CL et al. Food Safety and Foodborne Toxicants. Chapter 14 in Hayes' Principles and Methods of Toxicology, Sixth Edition. Eds A. Wallace Hayes, Claire L. Kruger. CRC Press, 2014 {{ISBN|9781842145371}}. Quote: "In humans. however. although the long-term use of Lorenzo's oil (oleic acid and erucic acid) in the treatment of adrenoleukodystrophy or adrenomyeloneuropathy leads to thrombocytopenia and lymphopenia (Unkrig et al. 1994), adverse effects from dietary consumption of erucic acid have not been reported."
18. ^Food Standards Australia New Zealand (June 2003) Erucic acid in food {{webarchive|url=https://web.archive.org/web/20081203120159/http://www.foodstandards.gov.au/_srcfiles/Erucic%20acid%20monograph.pdf |date=2008-12-03 }} : A Toxicological Review and Risk Assessment . Technical report series No. 21; Page 4 paragraph 1; {{ISBN|0-642-34526-0}}, ISSN 1448-3017
19. ^{{cite web|url=http://www.food.gov.uk/news/newsarchive/2004/sep/erucic|title=Food Standards Agency - Agency issues warning on erucic acid|accessdate=2007-11-02|format=|work=|date=2 September 2004}}

External links

  • The Myelin Project (international site)
  • Lorenzo and His Parents (official site of book)
{{DEFAULTSORT:Lorenzo's Oil}}

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