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词条 PBK (gene)
释义

  1. References

  2. Further reading

{{Infobox_gene}}Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene.[1][2][3]

The protein encoded by this gene is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.[4]

References

1. ^{{cite journal | vauthors = Abe Y, Matsumoto S, Kito K, Ueda N | title = Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells | journal = J Biol Chem | volume = 275 | issue = 28 | pages = 21525–31 |date=Aug 2000 | pmid = 10781613 | pmc = | doi = 10.1074/jbc.M909629199 }}
2. ^{{cite journal | vauthors = Gaudet S, Branton D, Lue RA | title = Characterization of PDZ-binding kinase, a mitotic kinase | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 10 | pages = 5167–72 |date=Jun 2000 | pmid = 10779557 | pmc = 25800 | doi = 10.1073/pnas.090102397 }}
3. ^{{cite web | title = Entrez Gene: PBK PDZ binding kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55872| accessdate = }}
4. ^{{cite web | title = Entrez Gene: PBK PDZ binding kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55872| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Zhao S, Dai J, Zhao W, etal |title=PDZ-binding kinase participates in spermatogenesis. |journal=Int. J. Biochem. Cell Biol. |volume=33 |issue= 6 |pages= 631–6 |year= 2001 |pmid= 11378444 |doi=10.1016/S1357-2725(01)00005-X }}
  • {{cite journal |vauthors=Simons-Evelyn M, Bailey-Dell K, Toretsky JA, etal |title=PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells. |journal=Blood Cells Mol. Dis. |volume=27 |issue= 5 |pages= 825–9 |year= 2003 |pmid= 11783945 |doi= 10.1006/bcmd.2001.0452 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal | vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
  • {{cite journal | vauthors=Nandi A, Tidwell M, Karp J, Rapoport AP |title=Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells. |journal=Blood Cells Mol. Dis. |volume=32 |issue= 1 |pages= 240–5 |year= 2004 |pmid= 14757441 |doi=10.1016/j.bcmd.2003.10.004 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Matsumoto S, Abe Y, Fujibuchi T, etal |title=Characterization of a MAPKK-like protein kinase TOPK. |journal=Biochem. Biophys. Res. Commun. |volume=325 |issue= 3 |pages= 997–1004 |year= 2005 |pmid= 15541388 |doi= 10.1016/j.bbrc.2004.10.133 }}
  • {{cite journal |vauthors=Sabio G, Arthur JS, Kuma Y, etal |title=p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. |journal=EMBO J. |volume=24 |issue= 6 |pages= 1134–45 |year= 2005 |pmid= 15729360 |doi= 10.1038/sj.emboj.7600578 | pmc=556394 }}
  • {{cite journal |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
  • {{cite journal | vauthors=Kim J, Bhinge AA, Morgan XC, Iyer VR |title=Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. |journal=Nat. Methods |volume=2 |issue= 1 |pages= 47–53 |year= 2005 |pmid= 15782160 |doi= 10.1038/nmeth726 }}
  • {{cite journal |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
  • {{cite journal |vauthors=Dougherty JD, Garcia AD, Nakano I, etal |title=PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. |journal=J. Neurosci. |volume=25 |issue= 46 |pages= 10773–85 |year= 2006 |pmid= 16291951 |doi= 10.1523/JNEUROSCI.3207-05.2005 }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
  • {{cite journal |vauthors=Nandi AK, Ford T, Fleksher D, etal |title=Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 1 |pages= 181–8 |year= 2007 |pmid= 17482142 |doi= 10.1016/j.bbrc.2007.04.125 }}
  • {{cite journal |vauthors=Oh SM, Zhu F, Cho YY, etal |title=T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. |journal=Cancer Res. |volume=67 |issue= 11 |pages= 5186–94 |year= 2007 |pmid= 17545598 |doi= 10.1158/0008-5472.CAN-06-4506 }}
  • {{cite journal |vauthors=Zhu F, Zykova TA, Kang BS, etal |title=Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. |journal=Gastroenterology |volume=133 |issue= 1 |pages= 219–31 |year= 2007 |pmid= 17631144 |doi= 10.1053/j.gastro.2007.04.048 }}
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