| 释义 |
- References
- Further reading
{{Underlinked|date=June 2016}}{{Infobox_gene}}Protocadherin beta-3 is a protein that in humans is encoded by the PCDHB3 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[3]
}}References1. ^{{cite journal | vauthors = Wu Q, Maniatis T | title = A striking organization of a large family of human neural cadherin-like cell adhesion genes | journal = Cell | volume = 97 | issue = 6 | pages = 779–90 |date=Jul 1999 | pmid = 10380929 | pmc = | doi =10.1016/S0092-8674(00)80789-8 }}
2. ^{{cite web | title = Entrez Gene: PCDHB3 protocadherin beta 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56132| accessdate = }}
3. ^{{cite web | title = Entrez Gene: PCDHB3 protocadherin beta 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56132| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Frank M, Kemler R |title=Protocadherins. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 557–62 |year= 2003 |pmid= 12231349 |doi=10.1016/S0955-0674(02)00365-4 }}
- {{cite journal | vauthors=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551–72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777 }}
- {{cite journal | vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi= 10.1101/gad.14.10.1169}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal | vauthors=Vanhalst K, Kools P, Vanden Eynde E, van Roy F |title=The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. |journal=FEBS Lett. |volume=495 |issue= 1–2 |pages= 120–5 |year= 2001 |pmid= 11322959 |doi=10.1016/S0014-5793(01)02372-9 }}
- {{cite journal |vauthors=Wu Q, Zhang T, Cheng JF, etal |title=Comparative DNA sequence analysis of mouse and human protocadherin gene clusters |journal=Genome Res. |volume=11 |issue= 3 |pages= 389–404 |year= 2001 |pmid= 11230163 |doi= 10.1101/gr.167301 | pmc=311048 }}
- {{cite journal | vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 }}
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