“PCGF2”的意思、由来-开放百科全书

Function

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.^[2]

References

1. ^{{cite journal | vauthors = Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M | title = Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif | journal = Gene | volume = 129 | issue = 2 | pages = 249–55 | date = July 1993 | pmid = 8325509 | pmc = | doi = 10.1016/0378-1119(93)90275-8 }}
2. ^¹{{cite web | title = Entrez Gene: PCGF2 polycomb group ring finger 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7703| accessdate = }}

Further reading

{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = March 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}

{{cite journal | vauthors = Kimura M, Koseki Y, Yamashita M, Watanabe N, Shimizu C, Katsumoto T, Kitamura T, Taniguchi M, Koseki H, Nakayama T | title = Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene | journal = Immunity | volume = 15 | issue = 2 | pages = 275–87 | date = August 2001 | pmid = 11520462 | doi = 10.1016/S1074-7613(01)00182-0 }}

{{cite journal | vauthors = Miyazaki K, Inoue H, Onai N, Ishihara H, Kanno M | title = Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18 | journal = Immunology Letters | volume = 80 | issue = 2 | pages = 139–43 | date = February 2002 | pmid = 11750047 | doi = 10.1016/S0165-2478(01)00315-7 }}

{{cite journal | vauthors = Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE | title = The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans | journal = Molecular and Cellular Biology | volume = 22 | issue = 17 | pages = 6070–8 | date = September 2002 | pmid = 12167701 | pmc = 134016 | doi = 10.1128/MCB.22.17.6070-6078.2002 }}

{{cite journal | vauthors = Suzuki M, Mizutani-Koseki Y, Fujimura Y, Miyagishima H, Kaneko T, Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H, Vidal M, Isono K, Koseki H | title = Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice | journal = Development | volume = 129 | issue = 18 | pages = 4171–83 | date = September 2002 | pmid = 12183370 | doi = }}

{{cite journal | vauthors = Matsuo F, Yano K, Saito H, Morotomi K, Kato M, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Miki Y | title = Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines | journal = Breast Cancer | volume = 9 | issue = 1 | pages = 33–8 | year = 2002 | pmid = 12196719 | doi = 10.1007/BF02967544 }}

{{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}

{{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}

{{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415–8 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}

{{cite journal | vauthors = Silva J, García JM, Peña C, García V, Domínguez G, Suárez D, Camacho FI, Espinosa R, Provencio M, España P, Bonilla F | title = Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas | journal = Clinical Cancer Research | volume = 12 | issue = 23 | pages = 6929–36 | date = December 2006 | pmid = 17145810 | doi = 10.1158/1078-0432.CCR-06-0788 }}

{{cite journal | vauthors = Guo WJ, Datta S, Band V, Dimri GP | title = Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins | journal = Molecular Biology of the Cell | volume = 18 | issue = 2 | pages = 536–46 | date = February 2007 | pmid = 17151361 | pmc = 1783768 | doi = 10.1091/mbc.E06-05-0447 }}

{{cite journal | vauthors = Wiederschain D, Chen L, Johnson B, Bettano K, Jackson D, Taraszka J, Wang YK, Jones MD, Morrissey M, Deeds J, Mosher R, Fordjour P, Lengauer C, Benson JD | title = Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis | journal = Molecular and Cellular Biology | volume = 27 | issue = 13 | pages = 4968–79 | date = July 2007 | pmid = 17452456 | pmc = 1951487 | doi = 10.1128/MCB.02244-06 }}

{{cite journal | vauthors = Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP | title = Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells | journal = Cancer Research | volume = 67 | issue = 11 | pages = 5083–9 | date = June 2007 | pmid = 17545584 | pmc = 2386662 | doi = 10.1158/0008-5472.CAN-06-4368 }}

{{cite journal | vauthors = Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M | title = Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns | journal = Genome Biology | volume = 8 | issue = 8 | pages = R154 | year = 2007 | pmid = 17672918 | pmc = 2374985 | doi = 10.1186/gb-2007-8-8-r154 }}