| 释义 |
- References
- Further reading
{{Underlinked|date=June 2016}}{{Infobox_gene}}Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]
}}References1. ^{{cite journal | vauthors = Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H | title = MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation | journal = Genes Cells | volume = 7 | issue = 8 | pages = 835–50 |date=Aug 2002 | pmid = 12167161 | pmc = | doi =10.1046/j.1365-2443.2002.00565.x }}
2. ^1 {{cite web | title = Entrez Gene: PCGF6 polycomb group ring finger 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84108| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Kanno M, Hasegawa M, Ishida A, etal |title=mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. |journal=EMBO J. |volume=14 |issue= 22 |pages= 5672–8 |year= 1996 |pmid= 8521824 |doi= | pmc=394682 }}
- {{cite journal | vauthors=Trimarchi JM, Fairchild B, Wen J, Lees JA |title=The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1519–24 |year= 2001 |pmid= 11171983 |doi= 10.1073/pnas.041597698 | pmc=29289 }}
- {{cite journal |vauthors=Suzuki M, Mizutani-Koseki Y, Fujimura Y, etal |title=Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. |journal=Development |volume=129 |issue= 18 |pages= 4171–83 |year= 2002 |pmid= 12183370 |doi= }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Deloukas P, Earthrowl ME, Grafham DV, etal |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
- {{cite journal | vauthors=Zhong N, Radu G, Ju W, Brown WT |title=Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 2 |pages= 855–61 |year= 2006 |pmid= 16248985 |doi= 10.1016/j.bbrc.2005.10.020 }}
- {{cite journal | vauthors=Lee MG, Norman J, Shilatifard A, Shiekhattar R |title=Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. |journal=Cell |volume=128 |issue= 5 |pages= 877–87 |year= 2007 |pmid= 17320162 |doi= 10.1016/j.cell.2007.02.004 }}
{{refend}}{{PDB Gallery|geneid=84108}}{{gene-10-stub}} |