| 词条 | PD-168,077 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 404930121 | IUPAC_name = N-([4-(2-cyanophenyl)piperazin-1-yl]methyl)-3-methylbenzamide | image = PD-168077_structure.png | tradename = | licence_EU = | pregnancy_category = | legal_UK = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 975 | ATC_suffix = | PubChem = 3645619 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 45244 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 2879553 | C=20 | H=22 | N=4 | O=1 | molecular_weight = 334.414 g/mol | smiles = Cc2cc(ccc2)C(=O)NCN(CC3)CCN3c1ccccc1C#N | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C20H22N4O/c1-16-5-4-7-17(13-16)20(25)22-15-23-9-11-24(12-10-23)19-8-3-2-6-18(19)14-21/h2-8,13H,9-12,15H2,1H3,(H,22,25) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = DNULYRGWTFLJQL-UHFFFAOYSA-N }}PD-168,077 is a drug which acts as a dopamine agonist selective for the D4 subtype,[1][2] which is used for researching the role of D4 receptors in the brain,[3][4][5] particularly relating to learning and memory.[6] References1. ^{{cite journal |vauthors=Clifford JJ, Waddington JL |title=Topographically based search for an "Ethogram" among a series of novel D(4) dopamine receptor agonists and antagonists |journal=Neuropsychopharmacology |volume=22 |issue=5 |pages=538–44 |date=May 2000 |pmid=10731629 |doi=10.1016/S0893-133X(99)00141-4 |url=}} {{Dopaminergics}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Matulenko MA, Hakeem AA, Kolasa T, Nakane M, Terranova MA, Uchic ME, Miller LN, Chang R, Donnelly-Roberts DL, Namovic MT, Moreland RB, Brioni JD, Stewart AO |title=Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists |journal=Bioorganic & Medicinal Chemistry |volume=12 |issue=13 |pages=3471–83 |date=July 2004 |pmid=15186832 |doi=10.1016/j.bmc.2004.04.035 |url=}} 3. ^{{cite journal |vauthors=Wang X, Zhong P, Gu Z, Yan Z |title=Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex |journal=Journal of Neuroscience |volume=23 |issue=30 |pages=9852–61 |date=October 2003 |pmid=14586014 |doi= |url=}} 4. ^{{cite journal |vauthors=Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A |title=PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain |journal=The European Journal of Neuroscience |volume=24 |issue=7 |pages=2021–30 |date=October 2006 |pmid=17067298 |doi=10.1111/j.1460-9568.2006.05043.x |url=}} 5. ^{{cite journal |vauthors=Succu S, Sanna F, Melis T, Boi A, Argiolas A, Melis MR |title=Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin |journal=Neuropharmacology |volume=52 |issue=3 |pages=1034–43 |date=March 2007 |pmid=17164075 |doi=10.1016/j.neuropharm.2006.10.019 |url=}} 6. ^{{cite journal |vauthors=Bernaerts P, Tirelli E |title=Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice |journal=Behavioural Brain Research |volume=142 |issue=1–2 |pages=41–52 |date=June 2003 |pmid=12798264 |doi= 10.1016/S0166-4328(02)00371-6|url=}} 4 : Dopamine agonists|Acetanilides|Piperazines|Nitriles |
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