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词条 PDS5B
释义

  1. Model organisms

  2. References

  3. Further reading

{{Infobox_gene}}Sister chromatid cohesion protein PDS5 homolog B is a protein that in humans is encoded by the PDS5B gene.[1][2][3]{{PBB_Summary
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Model organisms

Model organisms have been used in the study of PDS5B function. A conditional knockout mouse line, called Pds5btm1a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12]

Twenty three tests were carried out and two phenotypes were reported. Almost all homozygous mutant animals died prior to birth, and therefore they did not survive until weaning. The remaining tests were carried out on heterozygous mutant mice, and no significant abnormalities were observed.[5]

References

1. ^{{cite journal |vauthors=Couch FJ, Rommens JM, Neuhausen SL, Belanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J | title = Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13 | journal = Genomics | volume = 36 | issue = 1 | pages = 86–99 |date=Feb 1997 | pmid = 8812419 | pmc = | doi =10.1006/geno.1996.0428 |display-authors=etal}}
2. ^{{cite journal |vauthors=Geck P, Szelei J, Jimenez J, Sonnenschein C, Soto AM | title = Early gene expression during androgen-induced inhibition of proliferation of prostate cancer cells: a new suppressor candidate on chromosome 13, in the BRCA2-Rb1 locus | journal = J Steroid Biochem Mol Biol | volume = 68 | issue = 1–2 | pages = 41–50 |date=May 1999 | pmid = 10215036 | pmc = | doi =10.1016/S0960-0760(98)00165-4 }}
3. ^{{cite web | title = Entrez Gene: APRIN androgen-induced proliferation inhibitor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23047| accessdate = }}
4. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MAAN/citrobacter-challenge/ |title=Citrobacter infection data for Pds5b |publisher=Wellcome Trust Sanger Institute}}
5. ^1 2 {{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}
6. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
7. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Pds5b |title=International Knockout Mouse Consortium}}
8. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432978 |title=Mouse Genome Informatics}}
9. ^{{Cite journal| last1 = Skarnes |first1 =W. C.| doi = 10.1038/nature10163 | last2 = Rosen | first2 = B.| last3 = West | first3 = A. P.| last4 = Koutsourakis | first4 = M.| last5 = Bushell | first5 = W.| last6 = Iyer | first6 = V.| last7 = Mujica | first7 = A. O.| last8 = Thomas | first8 = M.| last9 = Harrow | first9 = J.| last10 = Cox | first10 = T.| last11 = Jackson | first11 = D.| last12 = Severin | first12 = J.| last13 = Biggs | first13 = P.| last14 = Fu | first14 = J.| last15 = Nefedov | first15 = M.| last16 = De Jong | first16 = P. J.| last17 = Stewart | first17 = A. F.| last18 = Bradley | first18 = A. | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | year = 2011 | pmid = 21677750 | pmc =3572410 }}
10. ^{{cite journal |author=Dolgin E |title=Mouse library set to be knockout |journal=Nature |volume=474 |issue=7351 |pages=262–3 |date=June 2011 |pmid=21677718 |doi=10.1038/474262a }}
11. ^{{cite journal |vauthors=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |date=January 2007 |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }}
12. ^{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=10.1093/dnares/6.1.63 }}
  • {{cite journal |vauthors=Geck P, Maffini MV, Szelei J, etal |title=Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 18 |pages= 10185–90 |year= 2000 |pmid= 10963680 |doi=10.1073/pnas.97.18.10185 | pmc=27796 }}
  • {{cite journal |vauthors=Maffini MV, Geck P, Powell CE, etal |title=Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate |journal=Endocrinology |volume=143 |issue= 7 |pages= 2708–14 |year= 2002 |pmid= 12072405 |doi=10.1210/en.143.7.2708 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
  • {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
  • {{cite journal |vauthors=Ballif BA, Villén J, Beausoleil SA, etal |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
  • {{cite journal |vauthors=Rankin S, Ayad NG, Kirschner MW |title=Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates |journal=Mol. Cell |volume=18 |issue= 2 |pages= 185–200 |year= 2005 |pmid= 15837422 |doi= 10.1016/j.molcel.2005.03.017 }}
  • {{cite journal |vauthors=Losada A, Yokochi T, Hirano T |title=Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts |journal=J. Cell Sci. |volume=118 |issue= Pt 10 |pages= 2133–41 |year= 2006 |pmid= 15855230 |doi= 10.1242/jcs.02355 }}
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1 : Genes mutated in mice
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