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词条 PDZK1
释义

  1. Interactions

  2. Related gene problems

  3. References

  4. Further reading

{{Infobox_gene}}Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.[1][2]

Interactions

PDZK1 has been shown to interact with:

  • AKAP10,[3]
  • CLCN3,[4]
  • Cystic fibrosis transmembrane conductance regulator[4][5]
  • FARP2,[3]
  • PDZK1IP1,[3][6][7]
  • SLC22A12,[3]
  • SLC22A4,[3]
  • SLC34A3,[3]
  • SLK,[3] and
  • Sodium-hydrogen antiporter 3 regulator 1.[3]

Related gene problems

  • TAR syndrome[8]
  • 1q21.1 deletion syndrome
  • 1q21.1 duplication syndrome

References

1. ^{{cite journal | vauthors = Kocher O, Comella N, Tognazzi K, Brown LF | title = Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains | journal = Lab Invest | volume = 78 | issue = 1 | pages = 117–25 | date = March 1998 | pmid = 9461128 | pmc = | doi = }}
2. ^{{cite web | title = Entrez Gene: PDZK1 PDZ domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5174| accessdate = }}
3. ^1 2 3 4 5 6 7 {{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney Int. | volume = 64 | issue = 5 | pages = 1733–45 | date = November 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}
4. ^1 {{cite journal | vauthors = Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR | title = The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6440–9 | date = February 2003 | pmid = 12471024 | doi = 10.1074/jbc.M211050200 }}
5. ^{{cite journal | vauthors = Wang S, Yue H, Derin RB, Guggino WB, Li M | title = Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity | journal = Cell | volume = 103 | issue = 1 | pages = 169–79 | date = September 2000 | pmid = 11051556 | doi = 10.1016/s0092-8674(00)00096-9}}
6. ^{{cite journal | vauthors = Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H | title = Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells | journal = Am. J. Physiol. Renal Physiol. | volume = 285 | issue = 4 | pages = F784-91 | date = October 2003 | pmid = 12837682 | doi = 10.1152/ajprenal.00109.2003 }}
7. ^{{cite journal | vauthors = Silver DL, Wang N, Vogel S | title = Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels | journal = J. Biol. Chem. | volume = 278 | issue = 31 | pages = 28528–32 | date = August 2003 | pmid = 12754212 | doi = 10.1074/jbc.M304109200 }}
8. ^{{cite journal | vauthors = Klopocki E, Schulze H, Strauss G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers HH, Ullmann R, Horn D, Mundlos S | title = Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome | journal = Am. J. Hum. Genet. | volume = 80 | issue = 2 | pages = 232–40 | date = February 2007 | pmid = 17236129 | pmc = 1785342 | doi = 10.1086/510919 | url = | issn = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = White KE, Biber J, Murer H, Econs MJ | title = A PDZ domain-containing protein with homology to Diphor-1 maps to human chromosome 1q21 | journal = Ann. Hum. Genet. | volume = 62 | issue = Pt 4 | pages = 287–90 | year = 1999 | pmid = 9924606 | doi = 10.1046/j.1469-1809.1998.6240287.x }}
  • {{cite journal | vauthors = Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown LF, Knoll JH | title = PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein | journal = Lab. Invest. | volume = 79 | issue = 9 | pages = 1161–70 | year = 1999 | pmid = 10496535 | doi = }}
  • {{cite journal | vauthors = Ikemoto M, Arai H, Feng D, Tanaka K, Aoki J, Dohmae N, Takio K, Adachi H, Tsujimoto M, Inoue K | title = Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 12 | pages = 6538–43 | year = 2000 | pmid = 10829064 | pmc = 18651 | doi = 10.1073/pnas.100114397 }}
  • {{cite journal | vauthors = Wang S, Yue H, Derin RB, Guggino WB, Li M | title = Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity | journal = Cell | volume = 103 | issue = 1 | pages = 169–79 | year = 2000 | pmid = 11051556 | doi = 10.1016/S0092-8674(00)00096-9 }}
  • {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA Cloning Using In Vitro Site-Specific Recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
  • {{cite journal | vauthors = Gisler SM, Stagljar I, Traebert M, Bacic D, Biber J, Murer H | title = Interaction of the type IIa Na/Pi cotransporter with PDZ proteins | journal = J. Biol. Chem. | volume = 276 | issue = 12 | pages = 9206–13 | year = 2001 | pmid = 11099500 | doi = 10.1074/jbc.M008745200 }}
  • {{cite journal | vauthors = Silver DL | title = A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver | journal = J. Biol. Chem. | volume = 277 | issue = 37 | pages = 34042–7 | year = 2002 | pmid = 12119305 | doi = 10.1074/jbc.M206584200 }}
  • {{cite journal | vauthors = Sellin L, Huber TB, Gerke P, Quack I, Pavenstädt H, Walz G | title = NEPH1 defines a novel family of podocin interacting proteins | journal = FASEB J. | volume = 17 | issue = 1 | pages = 115–7 | year = 2003 | pmid = 12424224 | doi = 10.1096/fj.02-0242fje }}
  • {{cite journal | vauthors = Gentzsch M, Cui L, Mengos A, Chang XB, Chen JH, Riordan JR | title = The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6440–9 | year = 2003 | pmid = 12471024 | doi = 10.1074/jbc.M211050200 }}
  • {{cite journal | vauthors = Hegedüs T, Sessler T, Scott R, Thelin W, Bakos E, Váradi A, Szabó K, Homolya L, Milgram SL, Sarkadi B | title = C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins | journal = Biochem. Biophys. Res. Commun. | volume = 302 | issue = 3 | pages = 454–61 | year = 2003 | pmid = 12615054 | doi = 10.1016/S0006-291X(03)00196-7 }}
  • {{cite journal | vauthors = Silver DL, Wang N, Vogel S | title = Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels | journal = J. Biol. Chem. | volume = 278 | issue = 31 | pages = 28528–32 | year = 2003 | pmid = 12754212 | doi = 10.1074/jbc.M304109200 }}
  • {{cite journal | vauthors = Pribanic S, Gisler SM, Bacic D, Madjdpour C, Hernando N, Sorribas V, Gantenbein A, Biber J, Murer H | title = Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells | journal = Am. J. Physiol. Renal Physiol. | volume = 285 | issue = 4 | pages = F784–91 | year = 2003 | pmid = 12837682 | doi = 10.1152/ajprenal.00109.2003 }}
  • {{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney Int. | volume = 64 | issue = 5 | pages = 1733–45 | year = 2004 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}
  • {{cite journal | vauthors = Kocher O, Yesilaltay A, Cirovic C, Pal R, Rigotti A, Krieger M | title = Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52820–5 | year = 2004 | pmid = 14551195 | doi = 10.1074/jbc.M310482200 }}
  • {{cite journal | vauthors = Inoue J, Otsuki T, Hirasawa A, Imoto I, Matsuo Y, Shimizu S, Taniwaki M, Inazawa J | title = Overexpression of PDZK1 within the 1q12-q22 Amplicon Is Likely To Be Associated with Drug-Resistance Phenotype in Multiple Myeloma | journal = Am. J. Pathol. | volume = 165 | issue = 1 | pages = 71–81 | year = 2004 | pmid = 15215163 | pmc = 1618545 | doi = 10.1016/S0002-9440(10)63276-2 }}
  • {{cite journal | vauthors = Anzai N, Miyazaki H, Noshiro R, Khamdang S, Chairoungdua A, Shin HJ, Enomoto A, Sakamoto S, Hirata T, Tomita K, Kanai Y, Endou H | title = The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus | journal = J. Biol. Chem. | volume = 279 | issue = 44 | pages = 45942–50 | year = 2004 | pmid = 15304510 | doi = 10.1074/jbc.M406724200 }}
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