| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.[1][2] PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.[3] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.[4]{{PBB_Summary
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}}InteractionsPEG3 has been shown to interact with SIAH2[5] and SIAH1.[5] References1. ^{{cite journal |vauthors=Kim J, Ashworth L, Branscomb E, Stubbs L | title = The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4 | journal = Genome Res | volume = 7 | issue = 5 | pages = 532–40 |date=August 1997 | pmid = 9149948 | pmc = 310658 | doi = 10.1101/gr.7.5.532}}
2. ^{{cite web | title = Entrez Gene: PEG3 paternally expressed 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5178| accessdate = }}
3. ^{{cite web|url=http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0083359|| volume = 8 | issue = 12 |author1=Michelle M. Thiaville |author2=Jennifer M. Huang |author3=Hana Kim |author4=Muhammad B. Ekram |author5=Arundhati Bakshi |author6=Tae-Young Roh |author7=Joomyeong Kim |date=December 31, 2013|| accessdate = May 22, 2014|title=Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families}}
4. ^{{cite journal |vauthors=Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J | title = DNA-binding motif and target genes of the imprinted transcription factor PEG3 | journal = Gene | volume = 512 | issue = 2 | pages = 314–320 |date=January 2013 | pmid = 23078764 | pmc = 3513644 | doi = 10.1016/j.gene.2012.10.005}}
5. ^1 {{cite journal |last=Relaix |first=F |authorlink= |author2=Wei X j |author3=Li W |author4=Pan J |author5=Lin Y |author6=Bowtell D D |author7=Sassoon D A |author8=Wu X |date=February 2000 |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue=5 |pages=2105–10 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10681424 |doi = 10.1073/pnas.040378897 | bibcode =2000PNAS...97.2105R | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=15761 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Relaix F, Wei XJ, Wu X, Sassoon DA |title=Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 287–91 |year= 1998 |pmid= 9500555 |doi= 10.1038/ng0398-287 }}
- {{cite journal |vauthors=Relaix F, Wei X, Li W, etal |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 5 |pages= 2105–10 |year= 2000 |pmid= 10681424 |doi= 10.1073/pnas.040378897 | pmc=15761 |bibcode=2000PNAS...97.2105R }}
- {{cite journal |vauthors=Kim J, Bergmann A, Stubbs L |title=Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). |journal=Genomics |volume=64 |issue= 1 |pages= 114–8 |year= 2000 |pmid= 10708526 |doi= 10.1006/geno.1999.6112 }}
- {{cite journal |vauthors=Kohda T, Asai A, Kuroiwa Y, etal |title=Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. |journal=Genes Cells |volume=6 |issue= 3 |pages= 237–47 |year= 2001 |pmid= 11260267 |doi=10.1046/j.1365-2443.2001.00412.x }}
- {{cite journal |vauthors=Hiby SE, Lough M, Keverne EB, etal |title=Paternal monoallelic expression of PEG3 in the human placenta. |journal=Hum. Mol. Genet. |volume=10 |issue= 10 |pages= 1093–100 |year= 2001 |pmid= 11331620 |doi=10.1093/hmg/10.10.1093 }}
- {{cite journal |vauthors=Yarden RI, Brody LC |title=Identification of proteins that interact with BRCA1 by Far-Western library screening. |journal=J. Cell. Biochem. |volume=83 |issue= 4 |pages= 521–31 |year= 2002 |pmid= 11746496 |doi=10.1002/jcb.1257 }}
- {{cite journal |vauthors=Johnson MD, Wu X, Aithmitti N, Morrison RS |title=Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23000–7 |year= 2002 |pmid= 11943780 |doi= 10.1074/jbc.M201907200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Mirey G, Chartrain I, Froment C, etal |title=CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. |journal=Cell Cycle |volume=4 |issue= 6 |pages= 806–11 |year= 2006 |pmid= 15908796 |doi= 10.4161/cc.4.6.1716}}
- {{cite journal |vauthors=Dowdy SC, Gostout BS, Shridhar V, etal |title=Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. |journal=Gynecol. Oncol. |volume=99 |issue= 1 |pages= 126–34 |year= 2005 |pmid= 16023706 |doi= 10.1016/j.ygyno.2005.05.036 }}
- {{cite journal |vauthors=Chartrain I, Couturier A, Tassan JP |title=Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. |journal=Biol. Cell |volume=98 |issue= 4 |pages= 253–63 |year= 2006 |pmid= 16159311 |doi= 10.1042/BC20050041 }}
- {{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
{{refend}}{{Transcription factors|g2}}{{protein-stub}} |