| 释义 |
- Function
- Interactions
- References
- Further reading
- External links
{{Infobox_gene|M6PRBP1}}Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene.[1] Its gene product, as well as the gene itself, is commonly known as TIP47. Function Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.[2]The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,[3] despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for lipid droplets.[4] TIP47 belongs to the peripilin protein family and shares significant homology with the other genes of this family, including perilipin and adipophilin.[5] InteractionsM6PRBP1 has been shown to interact with both Mannose 6-phosphate receptors.[6][7] References 1. ^{{cite web | title = Entrez Gene: M6PRBP1 mannose-6-phosphate receptor binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10226| accessdate = }}
2. ^{{cite journal |vauthors=Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR | title= Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. | journal = Science |volume = 292| issue = 5520 | pages = 1373–6 |date=May 2001| pmid= 11359012 | doi = 10.1126/science.1056791| url= | issn= |bibcode=2001Sci...292.1373C}}
3. ^{{cite journal |vauthors=Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, Burger KN, Höning S | title = TIP47 functions in the biogenesis of lipid droplets | journal = J. Cell Biol. | volume = 185 | issue = 4 | pages = 641–55 |date=May 2009 | pmid = 19451273 | doi = 10.1083/jcb.200812042 | url = http://pubman.mpdl.mpg.de/pubman/item/escidoc:588093/component/escidoc:2223664/588093.pdf| issn = | pmc = 2711566 }}
4. ^{{cite journal |vauthors=Ducharme NA, Bickel PE | title = Lipid droplets in lipogenesis and lipolysis | journal = Endocrinology | volume = 149 | issue = 3 | pages = 942–9 |date=March 2008 | pmid = 18202123 | doi = 10.1210/en.2007-1713 | url = | issn = }}
5. ^{{cite journal | author = Brasaemle DL | title = Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis | journal = J. Lipid Res. | volume = 48 | issue = 12 | pages = 2547–59 |date=December 2007 | pmid = 17878492 | doi = 10.1194/jlr.R700014-JLR200 | url = http://www.jlr.org/content/48/12/2547.full.pdf| issn = }}
6. ^{{cite journal |doi=10.1016/S0092-8674(00)81171-X |last=Díaz |first=E |authorlink= |author2=Pfeffer S R |date=May 1998 |title=TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking |journal=Cell |volume=93 |issue=3 |pages=433–43 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 9590177 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
7. ^{{cite journal |last=Orsel |first=J G |authorlink= |author2=Sincock P M |author3=Krise J P |author4=Pfeffer S R |date=August 2000 |title=Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue=16 |pages=9047–51 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10908666 |doi = 10.1073/pnas.160251397 | bibcode =2000PNAS...97.9047O | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16819 }}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Bohn H, Kraus W, Winckler W |title=Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). |journal=Oncodev. Biol. Med. |volume=4 |issue= 5 |pages= 343–50 |year= 1983 |pmid= 6856484 |doi= }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Díaz E, Pfeffer SR |title=TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. |journal=Cell |volume=93 |issue= 3 |pages= 433–43 |year= 1998 |pmid= 9590177 |doi=10.1016/S0092-8674(00)81171-X }}
- {{cite journal |vauthors=Than NG, Sumegi B, Than GN, etal |title=Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants. |journal=Eur. J. Biochem. |volume=258 |issue= 2 |pages= 752–7 |year= 1999 |pmid= 9874244 |doi=10.1046/j.1432-1327.1998.2580752.x }}
- {{cite journal |vauthors=Than NG, Sumegi B, Than GN, etal |title=Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein. |journal=Tumour Biol. |volume=20 |issue= 4 |pages= 184–92 |year= 1999 |pmid= 10393528 |doi=10.1159/000030062 }}
- {{cite journal |vauthors=Krise JP, Sincock PM, Orsel JG, Pfeffer SR |title=Quantitative analysis of TIP47-receptor cytoplasmic domain interactions: implications for endosome-to-trans Golgi network trafficking. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25188–93 |year= 2000 |pmid= 10829017 |doi= 10.1074/jbc.M001138200 }}
- {{cite journal |vauthors=Orsel JG, Sincock PM, Krise JP, Pfeffer SR |title=Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 9047–51 |year= 2000 |pmid= 10908666 |doi= 10.1073/pnas.160251397 | pmc=16819 |bibcode=2000PNAS...97.9047O }}
- {{cite journal |vauthors=Barbero P, Buell E, Zulley S, Pfeffer SR |title=TIP47 is not a component of lipid droplets. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24348–51 |year= 2001 |pmid= 11313361 |doi= 10.1074/jbc.M102468200 }}
- {{cite journal |vauthors=Carroll KS, Hanna J, Simon I, etal |title=Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. |journal=Science |volume=292 |issue= 5520 |pages= 1373–6 |year= 2001 |pmid= 11359012 |doi= 10.1126/science.1056791 |bibcode=2001Sci...292.1373C }}
- {{cite journal |vauthors=Hanna J, Carroll K, Pfeffer SR |title=Identification of residues in TIP47 essential for Rab9 binding. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7450–4 |year= 2002 |pmid= 12032303 |doi= 10.1073/pnas.112198799 | pmc=124251 |bibcode=2002PNAS...99.7450H }}
- {{cite journal |vauthors=Miura S, Gan JW, Brzostowski J, etal |title=Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 32253–7 |year= 2002 |pmid= 12077142 |doi= 10.1074/jbc.M204410200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Sincock PM, Ganley IG, Krise JP, etal |title=Self-assembly is important for TIP47 function in mannose 6-phosphate receptor transport. |journal=Traffic |volume=4 |issue= 1 |pages= 18–25 |year= 2003 |pmid= 12535272 |doi=10.1034/j.1600-0854.2003.40104.x }}
- {{cite journal |vauthors=Than NG, Sumegi B, Bellyei S, etal |title=Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells. |journal=Eur. J. Biochem. |volume=270 |issue= 6 |pages= 1176–88 |year= 2003 |pmid= 12631276 |doi=10.1046/j.1432-1033.2003.03475.x }}
- {{cite journal |vauthors=Nair P, Schaub BE, Rohrer J |title=Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24753–8 |year= 2003 |pmid= 12697764 |doi= 10.1074/jbc.M300174200 }}
- {{cite journal |vauthors=Blot G, Janvier K, Le Panse S, etal |title=Targeting of the human immunodeficiency virus type 1 envelope to the trans-Golgi network through binding to TIP47 is required for env incorporation into virions and infectivity. |journal=J. Virol. |volume=77 |issue= 12 |pages= 6931–45 |year= 2003 |pmid= 12768012 |doi=10.1128/JVI.77.12.6931-6945.2003 | pmc=156179 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
- {{cite journal |vauthors=Ganley IG, Carroll K, Bittova L, Pfeffer S |title=Rab9 GTPase regulates late endosome size and requires effector interaction for its stability. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5420–30 |year= 2005 |pmid= 15456905 |doi= 10.1091/mbc.E04-08-0747 | pmc=532021 }}
{{refend}}External links- {{UCSC genome browser|PLIN3}}
- {{UCSC gene details|PLIN3}}
{{Vesicular transport proteins}} |