| 释义 |
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{{Infobox_gene}}Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene.[1][2] It located on chromosome 2 next to KIAA1841InteractionsPEX13 has been shown to interact with PEX14,[3] PEX5[3][4] and PEX19.[5][6] References1. ^{{cite journal |vauthors=Bjorkman J, Stetten G, Moore CS, Gould SJ, Crane DI | title = Genomic structure of PEX13, a candidate peroxisome biogenesis disorder gene | journal = Genomics | volume = 54 | issue = 3 | pages = 521–8 |date=February 1999 | pmid = 9878256 | pmc = | doi = 10.1006/geno.1998.5520 }}
2. ^{{cite web | title = Entrez Gene: PEX13 peroxisome biogenesis factor 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5194| accessdate = }}
3. ^1 {{cite journal |last=Otera |first=Hidenori |authorlink= |author2=Setoguchi Kiyoko |author3=Hamasaki Maho |author4=Kumashiro Toshitaka |author5=Shimizu Nobuhiro |author6=Fujiki Yukio |date=March 2002 |title=Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import |journal=Mol. Cell. Biol. |volume=22 |issue=6 |pages=1639–55 | issn = 0270-7306| pmid = 11865044 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.22.6.1639-1655.2002 |pmc=135613 }}
4. ^{{cite journal |last=Gould |first=S J |authorlink= |author2=Kalish J E |author3=Morrell J C |author4=Bjorkman J |author5=Urquhart A J |author6=Crane D I |date=October 1996 |title=Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor |journal=J. Cell Biol. |volume=135 |issue=1 |pages=85–95 | issn = 0021-9525| pmid = 8858165 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1083/jcb.135.1.85 |pmc=2121023 }}
5. ^{{cite journal |last=Sacksteder |first=K A |authorlink= |author2=Jones J M |author3=South S T |author4=Li X |author5=Liu Y |author6=Gould S J |date=March 2000 |title=Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis |journal=J. Cell Biol. |volume=148 |issue=5 |pages=931–44 | issn = 0021-9525| pmid = 10704444 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1083/jcb.148.5.931 |pmc=2174547 }}
6. ^{{cite journal |last=Fransen |first=M |authorlink= |author2=Wylin T |author3=Brees C |author4=Mannaerts G P |author5=Van Veldhoven P P |date=July 2001 |title=Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences |journal=Mol. Cell. Biol. |volume=21 |issue=13 |pages=4413–24 | issn = 0270-7306| pmid = 11390669 |doi = 10.1128/MCB.21.13.4413-4424.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=87101 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Gould SJ, Kalish JE, Morrell JC, etal |title=Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor |journal=J. Cell Biol. |volume=135 |issue= 1 |pages= 85–95 |year= 1996 |pmid= 8858165 |doi=10.1083/jcb.135.1.85 | pmc=2121023 }}
- {{cite journal |vauthors=Albertini M, Rehling P, Erdmann R, etal |title=Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways |journal=Cell |volume=89 |issue= 1 |pages= 83–92 |year= 1997 |pmid= 9094717 |doi=10.1016/S0092-8674(00)80185-3 }}
- {{cite journal |vauthors=Fransen M, Terlecky SR, Subramani S |title=Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8087–92 |year= 1998 |pmid= 9653144 |doi=10.1073/pnas.95.14.8087 | pmc=20933 |bibcode=1998PNAS...95.8087F }}
- {{cite journal |vauthors=Girzalsky W, Rehling P, Stein K, etal |title=Involvement of Pex13p in Pex14p Localization and Peroxisomal Targeting Signal 2–dependent Protein Import into Peroxisomes |journal=J. Cell Biol. |volume=144 |issue= 6 |pages= 1151–62 |year= 1999 |pmid= 10087260 |doi=10.1083/jcb.144.6.1151 | pmc=2150583 }}
- {{cite journal |vauthors=Shimozawa N, Suzuki Y, Zhang Z, etal |title=Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders |journal=Hum. Mol. Genet. |volume=8 |issue= 6 |pages= 1077–83 |year= 1999 |pmid= 10332040 |doi=10.1093/hmg/8.6.1077 }}
- {{cite journal |vauthors=Toyama R, Mukai S, Itagaki A, etal |title=Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants |journal=Hum. Mol. Genet. |volume=8 |issue= 9 |pages= 1673–81 |year= 2000 |pmid= 10441330 |doi=10.1093/hmg/8.9.1673 }}
- {{cite journal |vauthors=Liu Y, Björkman J, Urquhart A, etal |title=PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders |journal=Am. J. Hum. Genet. |volume=65 |issue= 3 |pages= 621–34 |year= 1999 |pmid= 10441568 |doi=10.1086/302534 | pmc=1377968 }}
- {{cite journal |vauthors=Sacksteder KA, Jones JM, South ST, etal |title=Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis |journal=J. Cell Biol. |volume=148 |issue= 5 |pages= 931–44 |year= 2000 |pmid= 10704444 |doi=10.1083/jcb.148.5.931 | pmc=2174547 }}
- {{cite journal |vauthors=Fransen M, Wylin T, Brees C, etal |title=Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences |journal=Mol. Cell. Biol. |volume=21 |issue= 13 |pages= 4413–24 |year= 2001 |pmid= 11390669 |doi= 10.1128/MCB.21.13.4413-4424.2001 | pmc=87101 }}
- {{cite journal |vauthors=Jones JM, Morrell JC, Gould SJ |title=Multiple Distinct Targeting Signals in Integral Peroxisomal Membrane Proteins |journal=J. Cell Biol. |volume=153 |issue= 6 |pages= 1141–50 |year= 2001 |pmid= 11402059 |doi=10.1083/jcb.153.6.1141 | pmc=2192020 }}
- {{cite journal |vauthors=Otera H, Setoguchi K, Hamasaki M, etal |title=Peroxisomal Targeting Signal Receptor Pex5p Interacts with Cargoes and Import Machinery Components in a Spatiotemporally Differentiated Manner: Conserved Pex5p WXXXF/Y Motifs Are Critical for Matrix Protein Import |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1639–55 |year= 2002 |pmid= 11865044 |doi=10.1128/MCB.22.6.1639-1655.2002 | pmc=135613 }}
- {{cite journal |vauthors=Fransen M, Brees C, Ghys K, etal |title=Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay |journal=Mol. Cell. Proteomics |volume=1 |issue= 3 |pages= 243–52 |year= 2002 |pmid= 12096124 |doi=10.1074/mcp.M100025-MCP200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Fransen M, Vastiau I, Brees C, etal |title=Potential role for Pex19p in assembly of PTS-receptor docking complexes |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12615–24 |year= 2004 |pmid= 14715663 |doi= 10.1074/jbc.M304941200 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Hashimoto K, Kato Z, Nagase T, etal |title=Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder |journal=Pediatr. Res. |volume=58 |issue= 2 |pages= 263–9 |year= 2005 |pmid= 16006427 |doi= 10.1203/01.PDR.0000169984.89199.69 }}
- {{cite journal |vauthors=Nguyen T, Bjorkman J, Paton BC, Crane DI |title=Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance |journal=J. Cell Sci. |volume=119 |issue= Pt 4 |pages= 636–45 |year= 2006 |pmid= 16449325 |doi= 10.1242/jcs.02776 }}
{{refend}}External links- [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=pbd GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]
- [https://www.ncbi.nlm.nih.gov/omim/170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666,170993,202370,214100,266510,600279,600414,601498,601758,601789,601791,602136,602859,603164,603360,608666 OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum]
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