| 释义 |
- References
- Further reading
{{Infobox_gene}}6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.[2]
}}References1. ^{{cite journal |vauthors=Batra RS, Hatchwell E, Rider S, Brown R, Brown GK, Craig IW | title = Localization of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1) within a YAC contig in Xp11.21 | journal = Genomics | volume = 40 | issue = 2 | pages = 358–61 |date=Apr 1997 | pmid = 9119406 | pmc = | doi = 10.1006/geno.1996.4530 }}
2. ^1 {{cite web | title = Entrez Gene: PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5207| accessdate = }}
Further reading{{refbegin | colwidth=25em}}- {{cite journal |vauthors=Lange AJ, Pilkis SJ |title=Sequence of human liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase |journal=Nucleic Acids Res. |volume=18 |issue= 12 |pages= 3652 |year= 1990 |pmid= 2163524 |doi=10.1093/nar/18.12.3652 | pmc=331036 }}
- {{cite journal | author=Marker AJ |title=Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression |journal=J. Biol. Chem. |volume=264 |issue= 12 |pages= 7000–4 |year= 1989 |pmid= 2540168 |doi= |name-list-format=vanc| author2=Colosia AD | author3=Tauler A | display-authors=3 | last4=Solomon | first4=DH | last5=Cayre | first5=Y | last6=Lange | first6=AJ | last7=El-Maghrabi | first7=MR | last8=Pilkis | first8=SJ }}
- {{cite journal |vauthors=Algaier J, Uyeda K |title=Molecular cloning, sequence analysis, and expression of a human liver cDNA coding for fructose-6-P,2-kinase:fructose-2,6-bisphosphatase |journal=Biochem. Biophys. Res. Commun. |volume=153 |issue= 1 |pages= 328–33 |year= 1988 |pmid= 2837207 |doi=10.1016/S0006-291X(88)81226-9 }}
- {{cite journal |vauthors=Lee YH, Li Y, Uyeda K, Hasemann CA |title=Tissue-specific structure/function differentiation of the liver isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 523–30 |year= 2003 |pmid= 12379646 |doi= 10.1074/jbc.M209105200 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Ross MT |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |name-list-format=vanc| author2=Grafham DV | author3=Coffey AJ | display-authors=3 | last4=Scherer | first4=Steven | last5=McLay | first5=Kirsten | last6=Muzny | first6=Donna | last7=Platzer | first7=Matthias | last8=Howell | first8=Gareth R. | last9=Burrows | first9=Christine }}
- {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-format=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
{{refend}}{{PDB Gallery|geneid=5207}}{{Glycolysis enzymes}}{{gene-X-stub}} |