| 词条 | Phenylethylidenehydrazine |
| 释义 |
| IUPAC_name = (1E)-(2-Phenylethylidene)hydrazine | image = Phenylethylidenehydrazine.svg | tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = ~12 hours | excretion = | CAS_number = 29443-41-2 | ATC_prefix = none | ATC_suffix = | PubChem = 10103216 | ChemSpiderID = 8278744 | C=8 | H=10 | N=2 | molecular_weight = 134.18 g/mol | smiles = N/N=C/CC1=CC=CC=C1 }} Phenylethylidenehydrazine (PEH), also known as 2-phenylethylhydrazone or β-phenylethylidenehydrazine, is an inhibitor of the enzyme GABA transaminase (GABA-T).[1][2] It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations.[1] PEH may contribute to phenelzine's anxiolytic effects.{{Citation needed|date=January 2016}} See also
References1. ^1 {{cite journal | vauthors = Parent MB, Master S, Kashlub S, Baker GB | title = Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum | journal = Biochemical Pharmacology | volume = 63 | issue = 1 | pages = 57–64 |date=January 2002 | pmid = 11754874 | doi = 10.1016/S0006-2952(01)00856-5| url = http://linkinghub.elsevier.com/retrieve/pii/S0006295201008565}} {{Anxiolytics}}{{GABA metabolism and transport modulators}}2. ^{{cite journal | vauthors = Duffy S, Nguyen PV, Baker GB | title = Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices | journal = Neuroscience | volume = 126 | issue = 2 | pages = 423–32 | year = 2004 | pmid = 15207360 | doi = 10.1016/j.neuroscience.2004.03.007 | url = http://linkinghub.elsevier.com/retrieve/pii/S0306452204001873}} 3 : Hydrazones|GABA transaminase inhibitors|Human drug metabolites |
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