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词条 PHF1
释义

  1. Function

  2. References

  3. Further reading

  4. External links

{{Infobox_gene}}PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.[1][2][3]

Function

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.[3]

References

1. ^{{cite journal | vauthors = Coulson M, Robert S, Eyre HJ, Saint R | title = The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster | journal = Genomics | volume = 48 | issue = 3 | pages = 381–3 | date = March 1998 | pmid = 9545646 | pmc = | doi = 10.1006/geno.1997.5201 }}
2. ^{{cite journal | vauthors = Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A | title = A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell | journal = Nucleic Acids Research | volume = 36 | issue = 9 | pages = 2939–47 | date = May 2008 | pmid = 18385154 | pmc = 2396414 | doi = 10.1093/nar/gkn146 }}
3. ^1 {{cite web | title = Entrez Gene: PHF1 PHD finger protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5252| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y | title = Role of hPHF1 in H3K27 methylation and Hox gene silencing | journal = Molecular and Cellular Biology | volume = 28 | issue = 5 | pages = 1862–72 | date = March 2008 | pmid = 18086877 | pmc = 2258785 | doi = 10.1128/MCB.01589-07 }}
  • {{cite journal | vauthors = O'Connell S, Wang L, Robert S, Jones CA, Saint R, Jones RS | title = Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein | journal = The Journal of Biological Chemistry | volume = 276 | issue = 46 | pages = 43065–73 | date = November 2001 | pmid = 11571280 | doi = 10.1074/jbc.M104294200 }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
{{refend}}

External links

  • {{MeshName|PHF1+protein,+human}}
{{NLM content}}{{Transcription factors|g3}}{{gene-6-stub}}

1 : Transcription factors
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