| 词条 | Phikmvlikevirus | ||||||||||||||||||||||||||||
| 释义 |
| virus_group = i | ordo = Caudovirales | familia = Podoviridae | subfamilia = Autographivirinae | genus = Phikmvlikevirus | subdivision_ranks = Type Species | subdivision =
}}Phikmvlikevirus is a genus of viruses that infect bacteria. There are currently four species in this genus including the type species Pseudomonas phage phiKMV.[1][2] Bacteriophage phiKMV[3] and its relatives are known to be highly virulent phages, producing large ({{Convert|3|-|15|mm|abbr=on}} diameter) clear plaques on a susceptible host.[4][5] The only reported exception is phage LKA1, which yields small plaques ({{Convert|1|mm|abbr=on}}) surrounded by a halo. While all other P. aeruginosa-specific phikmvlikeviruses use the Type IV pili as primary receptor, LKA1 particles attach to the bacterial lipopolysaccharide layer. TaxonomyGroup: dsDNA{{Collapsible list|title= Order: Caudovirales|1={{Collapsible list| framestyle=border:none; padding:1.0em;|title=Family: Podoviridae |1={{Collapsible list| framestyle=border:none; padding:1.0em;|title=Sub-Family: Autographivirinae |1={{hidden begin|title=Genus: Phikmvlikevirus}}
}} }} }}[2] VirologyElectron microscopic imaging of purified phage particles revealed these phages as typical members of the Podoviridae, with a head diameter of approximately {{Convert|60|nm|abbr=on}} and a stubby tail with a length of 8–10 nm. Although phiKMV phage resembles the well-studied podovirus T7 in overall genome architecture, it was the first known T7-like phage which encoded a single-subunit RNA polymerase gene downstream its DNA metabolism genes instead of in the early genomic region. Based on these properties, the genus Phikmvlikevirus is classified within the Autographivirinae.[6]
Life cycleViral replication is cytoplasmic. Entry into the host cell is achieved by absorption into the host cell. DNA-templated transcription is the method of transcription. The virus exits the host cell by lysis, and holin/endolysin/spanin proteins. Bacteria serve as the natural host. Transmission routes are passive diffusion.[1]
References1. ^1 {{cite web|title=Viral Zone|url=http://viralzone.expasy.org/all_by_species/710.html|publisher=ExPASy|accessdate=15 June 2015}} 2. ^1 {{cite web|last1=ICTV|title=Virus Taxonomy: 2014 Release|url=http://ictvonline.org/virusTaxonomy.asp|accessdate=15 June 2015}} 3. ^{{cite journal |last1=Lavigne |first1=Rob |last2=Burkal'tseva |first2=Maria V. |last3=Robben |first3=Johan |last4=Sykilinda |first4=Nina N. |last5=Kurochkina |first5=Lidia P. |last6=Grymonprez |first6=Barbara |last7=Jonckx |first7=Bart |last8=Krylov |first8=Victor N. |last9=Mesyanzhinov |first9=Vadim V. |last10=Volckaert |first10=Guido |title=The genome of bacteriophage φKMV, a T7-like virus infecting Pseudomonas aeruginosa |journal=Virology |volume=312 |issue=1 |pages=49–59 |year=2003 |pmid=12890620 |doi=10.1016/S0042-6822(03)00123-5|display-authors=8 }} 4. ^{{cite journal |last1=Ceyssens |first1=P.-J. |last2=Lavigne |first2=R. |last3=Mattheus |first3=W. |last4=Chibeu |first4=A. |last5=Hertveldt |first5=K. |last6=Mast |first6=J. |last7=Robben |first7=J. |last8=Volckaert |first8=G. |title=Genomic Analysis of Pseudomonas aeruginosa Phages LKD16 and LKA1: Establishment of the KMV Subgroup within the T7 Supergroup |journal=Journal of Bacteriology |volume=188 |issue=19 |pages=6924–31 |year=2006 |pmid=16980495 |pmc=1595506 |doi=10.1128/JB.00831-06}} 5. ^{{cite journal |last1=Lammens |first1=E. |last2= Ceyssens |first2=P.-J. |last3=Voet |first3=M. |last4=Hertveldt |first4=K. |last5= Lavigne |first5=R. | last6=Volckaert |first6=G. |title= Representational Difference Analysis (RDA) of bacteriophage genomes |journal= Journal of Microbiological Methods |volume=77 |issue=2 |pages=207–13 |year=2009|pmid=19232531 |doi=10.1016/j.mimet.2009.02.006}} 6. ^{{cite journal |last1=Lavigne |first1=Rob |last2=Seto |first2=Donald |last3=Mahadevan |first3=Padmanabhan |last4=Ackermann |first4=Hans-W. |last5=Kropinski |first5=Andrew M. |title=Unifying classical and molecular taxonomic classification: analysis of the Podoviridae using BLASTP-based tools |journal=Research in Microbiology |volume=159 |issue=5 |pages=406–14 |year=2008 |pmid=18555669 |doi=10.1016/j.resmic.2008.03.005}} External links
2 : Podoviridae|Autographivirinae |
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