| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.[3]
}}InteractionsPHLDA1 has been shown to interact with RPL14,[4] EIF3D[4] and PABPC4.[4] References1. ^{{cite journal |vauthors=Neef R, Kuske MA, Prols E, Johnson JP | title = Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation | journal = Cancer Res | volume = 62 | issue = 20 | pages = 5920–9 |date=Oct 2002 | pmid = 12384558 | pmc = | doi = }}
2. ^{{cite journal |author1=Toyoshima Y |author2=Karas M |author3=Yakar S |author4=Dupont J |author5=Lee Helman |author6=LeRoith D | title = TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival | journal = J Biol Chem | volume = 279 | issue = 24 | pages = 25898–904 |date=Jun 2004 | pmid = 15037619 | pmc = | doi = 10.1074/jbc.M400661200 }}
3. ^1 {{cite web | title = Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22822| accessdate = }}
4. ^1 2 {{cite journal |last=Hinz |first=T |authorlink= |author2=Flindt S |author3=Marx A |author4=Janssen O |author5=Kabelitz D |date=May 2001 |title=Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product |journal=Cell. Signal. |volume=13 |issue=5 |pages=345–52 |publisher= |location = England| issn = 0898-6568| pmid = 11369516 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0898-6568(01)00141-3 }}
Further reading{{refbegin}}- {{cite journal |vauthors=Reddy PH, Stockburger E, Gillevet P, Tagle DA |title=Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method. |journal=Genomics |volume=46 |issue= 2 |pages= 174–82 |year= 1998 |pmid= 9417904 |doi= 10.1006/geno.1997.5044 }}
- {{cite journal |vauthors=Kuske MD, Johnson JP |title=Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1–2 |pages= 1 |year= 2000 |pmid= 10894922 |doi=10.1159/000015575 }}
- {{cite journal |vauthors=Hinz T, Flindt S, Marx A, etal |title=Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product |journal=Cell. Signal. |volume=13 |issue= 5 |pages= 345–52 |year= 2001 |pmid= 11369516 |doi=10.1016/S0898-6568(01)00141-3 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Hossain GS, van Thienen JV, Werstuck GH, etal |title=TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30317–27 |year= 2003 |pmid= 12738777 |doi= 10.1074/jbc.M212897200 }}
- {{cite journal |vauthors=Oberg HH, Sipos B, Kalthoff H, etal |title=Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells |journal=Cell Death Differ. |volume=11 |issue= 6 |pages= 674–84 |year= 2005 |pmid= 15002043 |doi= 10.1038/sj.cdd.4401407 }}
- {{cite journal |vauthors=Meier-Noorden M, Flindt S, Kalinke U, Hinz T |title=A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation |journal=Gene |volume=338 |issue= 2 |pages= 197–207 |year= 2004 |pmid= 15315823 |doi= 10.1016/j.gene.2004.05.006 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
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