“Phosphatidylinositol-3,4-bisphosphate 4-phosphatase”的意思、由来-开放百科全书

词条

Phosphatidylinositol-3,4-bisphosphate 4-phosphatase

释义

References

{{enzyme
| Name = phosphatidylinositol-3,4-bisphosphate 4-phosphatase
| EC_number = 3.1.3.66
| CAS_number = 122653-78-5
| IUBMB_EC_number = 3/1/3/66
| GO_code = 0016316
| image =
| width =
| caption =
}}

In enzymology, a phosphatidylinositol-3,4-bisphosphate 4-phosphatase ({{EC number|3.1.3.66}}) is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H₂O 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate

Thus, the two substrates of this enzyme are 1-phosphatidyl-myo-inositol 3,4-bisphosphate and H₂O, whereas its two products are 1-phosphatidyl-1D-myo-inositol 3-phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase. Other names in common use include inositol-3,4-bisphosphate 4-phosphatase, D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase, phosphoinositide 4-phosphatase, inositol polyphosphate 4-phosphatase, D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase, and inositol polyphosphate 4-phosphatase type II. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

References

{{cite journal | vauthors = Howell S, Barnaby RJ, Rowe T, Ragan CI, Gee NS | date = 1989 | title = Evidence for at least four different inositol bisphosphatases in bovine brain | journal = Eur. J. Biochem. | volume = 183 | pages = 169–72 | pmid = 2546770 | doi = 10.1111/j.1432-1033.1989.tb14909.x | issue = 1 }}
{{cite journal | vauthors = Norris FA, Auethavekiat V, Majerus PW | date = 1995 | title = The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase | journal = J. Biol. Chem. | volume = 270 | pages = 16128–33 | pmid = 7608176 | doi = 10.1074/jbc.270.27.16128 | issue = 27 }}
{{cite journal | vauthors = Norris FA, Atkins RC, Majerus PW | date = 1997 | title = The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family | journal = J. Biol. Chem. | volume = 272 | pages = 23859–64 | pmid = 9295334 | doi = 10.1074/jbc.272.38.23859 | issue = 38 }}

2 : EC 3.1.3|Enzymes of unknown structure

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