“Phosphoribosyl-AMP cyclohydrolase”的意思、由来-开放百科全书

词条

Phosphoribosyl-AMP cyclohydrolase

释义

Structural studies
References

{{enzyme
| Name = phosphoribosyl-AMP cyclohydrolase
| EC_number = 3.5.4.19
| CAS_number = 37289-22-8
| IUBMB_EC_number = 3/5/4/19
| GO_code = 0004635
| image =
| width =
| caption =
}}

In enzymology, a phosphoribosyl-AMP cyclohydrolase ({{EC number|3.5.4.19}}) is an enzyme that catalyzes the chemical reaction

1-(5-phosphoribosyl)-AMP + H₂O 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4-carboxamide

Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-AMP and H₂O, whereas its two products are 1-(5-phosphoribosyl)-5-[(5- and phosphoribosylamino)methylideneamino]imidazole-4-carboxamide.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase. Other names in common use include PRAMP-cyclohydrolase, and phosphoribosyladenosine monophosphate cyclohydrolase. This enzyme participates in histidine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|1ZPS}}.

References

{{cite journal | vauthors = Minson AC, Creaser EH | author-link = Tony Minson | year = 1969 | title = Purification of a trifunctional enzyme, catalysing three steps of the histidine pathway, from Neurospora crassa | journal = Biochem. J. | volume = 114 | pages = 49–56 | pmid = 4309307 | issue = 1 | pmc = 1184794 | doi=10.1042/bj1140049}}

{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.4|Enzymes of known structure

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