“Phosphoserine phosphatase”的意思、由来-开放百科全书

词条

Phosphoserine phosphatase

释义

Structural studies
References

{{enzyme
| Name = phosphoserine phosphatase
| EC_number = 3.1.3.3
| CAS_number = 9025-73-4
| IUBMB_EC_number = 3/1/3/3
| GO_code = 0004647
| image =
| width =
| caption =
}}

In enzymology, a phosphoserine phosphatase ({{EC number|3.1.3.3}}) is an enzyme that catalyzes the following chemical reaction:

O-phospho-L(or D)-serine + H₂O L(or D)-serine + phosphate ion

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is O-phosphoserine phosphohydrolase. This enzyme participates in glycine, serine and threonine metabolism.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1F5S}}, {{PDB link|1J97}}, {{PDB link|1L7M}}, {{PDB link|1L7N}}, {{PDB link|1L7O}}, {{PDB link|1L7P}}, {{PDB link|1L8L}}, {{PDB link|1L8O}}, {{PDB link|1NNL}}, {{PDB link|2J6Y}}, {{PDB link|2J6Z}}, and {{PDB link|2J70}}.

References

{{cite journal | vauthors = BORKENHAGEN LF, KENNEDY EP | date = 1959 | title = The enzymatic exchange of L-serine with O-phospho-L-serine catalyzed by a specific phosphatase | journal = J. Biol. Chem. | volume = 234 | pages = 849–53 | pmid = 13654276 | issue = 4 }}
Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 73-78.
{{cite journal | vauthors = Neuhaus FC, Byrne WL | date = 1959 | title = Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase | journal = J. Biol. Chem. | volume = 234 | issue = 1 | pages = 113–121 | pmid=13610904}}

2 : EC 3.1.3|Enzymes of known structure

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