Pick 6 may refer to:

• Pick Six Podcast, a daily American football podcast presented by CBS Sports Digital. The show is hosted by CBS Sports Senior National Football League (NFL) Writer Will Brinson. The show is frequented by CBS personalities such as Ryan Wilson, John Breech, Sean Warner-McGough, Pete Prisco, Brady Quinn, Jason La Canfora, Nick Kostos, Chris Trapasso, and R.J. White.
• Pick 6 (horse racing), a wager in which a bettor picks one horse in each of six races
• Pick 6 (lottery), a game in which six regular numbers are picked
• Pick 6 (American football), an interception returned for a touchdown
• "Pick Six", a ranking system used by Ring of Honor to determine championship contenders

• Guenther Csar
• Guenther Kuelsen
• Guenther Landgraf
• Guenther Mader
• Guenther Oettinger
• Guenther's dikdik
• Guenther Stein
• Guenther Uecker
• Guenther Wendt
• Guenzburg
• Gueorgui Makharadze
• Guepard class destroyer
• Guepinia spathularia
• Guer
• Guera Department
• Gueral
• Guera Prefecture
• Guera Region
• Guerbet
• Guerbet reaction
• Guercheville
• Guerciotti
• Guere
• Guereda
• Guereins