| 词条 | Piclozotan |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 451554695 | IUPAC_name = 3-chloro-4-[4-[4-(2-pyridinyl)-1,2,3,6-tetrahydropyridin-1-yl]butyl]-1,4-benzoxazepin-5(4H)-one | image = Piclozotan.png | tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 182415-09-4 | ATC_prefix = | ATC_suffix = | PubChem = 9801640 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | UNII_Ref = {{fdacite|correct|FDA}} | UNII = FQE44HS7AH | ChemSpiderID = 7977402 | C=23 | H=24 | Cl=1 | N=3 | O=2 | molecular_weight = 409.909 g/mol | smiles = C1CN(CC=C1C2=CC=CC=N2)CCCCN3C(=COC4=CC=CC=C4C3=O)Cl | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C23H24ClN3O2/c24-22-17-29-21-9-2-1-7-19(21)23(28)27(22)14-6-5-13-26-15-10-18(11-16-26)20-8-3-4-12-25-20/h1-4,7-10,12,17H,5-6,11,13-16H2 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = URMTUEWUIGOJBW-UHFFFAOYSA-N }}Piclozotan (SUN-N4057) is a selective 5-HT1A receptor partial agonist, which has neuroprotective effects in animal studies.[1] It has been through early clinical trials in humans for treatment of acute stroke, but results have not yet been announced.[2][3] See also
References1. ^{{Cite journal| doi = 10.1016/j.bmc.2005.10.046| pmid = 16290165| year = 2006| last1 = Kamei | first1 = K.| last2 = Maeda | first2 = N.| last3 = Nomura | first3 = K.| last4 = Shibata | first4 = M.| last5 = Katsuragi-Ogino | first5 = R.| last6 = Koyama | first6 = M.| last7 = Nakajima | first7 = M.| last8 = Inoue | first8 = T.| last9 = Ohno | first9 = T.| last10 = Tatsuoka | first10 = T.| title = Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan| volume = 14| issue = 6| pages = 1978–1992| journal = Bioorganic & Medicinal Chemistry }} {{Serotonergics}}{{nervous-system-drug-stub}}2. ^{{Cite journal| doi = 10.1159/000091712| pmid = 16651823| year = 2006| last1 = Ferro | first1 = J.| last2 = Dávalos | first2 = A.| title = Other neuroprotective therapies on trial in acute stroke| volume = 21 Suppl 2| issue = 2| pages = 127–130| journal = Cerebrovascular diseases (Basel, Switzerland) }} 3. ^{{Cite journal| doi = 10.1097/MJT.0b013e31816b8c85| pmid = 19300037| year = 2009| last1 = Mondick | first1 = J.| last2 = Oo | first2 = C.| last3 = Patel | first3 = D.| last4 = Fujitani | first4 = T.| last5 = Shimizu | first5 = K.| last6 = Barrett | first6 = J.| title = Population pharmacokinetics of the selective serotonin 5-HT1A receptor partial agonist piclozotan| volume = 16| issue = 2| pages = 106–115| journal = American Journal of Therapeutics }} 5 : Carboxamides|Benzoxazepines|Pyridines|Lactams|Organochlorides |
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