| 词条 | Picobirnavirus | ||||||||||||||||||||||||||||
| 释义 |
| taxon = Picobirnavirus | type_species = Human picobirnavirus }}Picobirnavirus is a genus of dsRNA viruses, the only genus in the family Picobirnaviridae. Although amniotes, especially mammals, were thought to serve as hosts, it has been recently suggested that these viruses might infect bacteria.[1] There are currently only two species in this genus including the type species human picobirnavirus. Associated symptoms include gastroenteritis in animals and humans, though the disease association is unclear.[2][3] HistoryFirst detection of picobirnavirus (PBV) was in humans and black-footed pigmy rice rats in 1988.[4] Life cycleViral replication is cytoplasmic. Entry into the host cell is achieved by penetration into the host cell. Replication follows the double-stranded RNA virus replication model. Double-stranded RNA virus transcription is the method of transcription. Mammals serve as the natural host. Transmission routes are fecal-oral.[2]
StructureViruses in picobirnavirus are non-enveloped, with icosahedral geometries, and T=3 symmetry. The diameter is around 35-40 nm.[2]
GenomeThe genome is linear, bipartite, and composed of double-stranded RNA. It includes a segment 1 – 2.5 (2.2–2.7) kilobases (kb) length and a segment 2 – 1.7 (1.2–1.9) kb in length. The genome codes for 3 to 4 proteins.[2] The capsid protein gene is encoded by the second open reading frame of the larger genomic segment. These viruses are divided into two genogroups on the basis of the sequence of segment 2. They have been isolated from humans and other mammals, as well as birds and squamates.[5] Any role in disease is not yet clear. ClassificationPBV was initially thought to belong to family Birnaviridae but later confirmed to differ with respect to host, virion size, capsid, RNA polymerase, genome size, and organization. Now PBV has been classified distinctly[6] A new viral family named Picobirnaviridae under the proposed order Diplornavirales was created to accommodate this unique virus and a complete new taxonomic order was assigned . This new viral family is composed of only one viral genus, Picobirnavirus. The two species under the genus are human Picobirnavirus and rabbit Picobirnavirus, where the former one is nominated as a type species and the latter one was designated species by the International Committee on Taxonomy of Viruses in 2008. The nomenclature of the virus has been derived from its size and genome characteristics: the prefix “pico” signifies the small diameter of the viral particle (35 nm) and “birna” comes from the genome composed of two segments of dsRNA. TaxonomyGroup: dsRNA{{Collapsible list|title= Order: Unassigned|1={{Collapsible list| framestyle=border:none; padding:1.0em;|title=Family: Picobirnaviridae |1={{hidden begin|title=Genus: Picobirnavirus}}
}} }}[3] References1. ^{{cite journal|last1=Krishnamurthy|first1=Siddharth R.|last2=Wang|first2=David|title=Extensive conservation of prokaryotic ribosomal binding sites in known and novel picobirnaviruses|journal=Virology|date=1 March 2018|volume=516|pages=108–114|doi=10.1016/j.virol.2018.01.006|pmid=29346073|language=en|issn=0042-6822}} 2. ^1 2 3 {{cite web|title=Viral Zone|url=http://viralzone.expasy.org/all_by_species/602.html|publisher=ExPASy|accessdate=15 June 2015}} 3. ^1 {{cite web|last1=ICTV|title=Virus Taxonomy: 2014 Release|url=http://ictvonline.org/virusTaxonomy.asp|accessdate=15 June 2015}} 4. ^{{cite journal | last1 = Pereira | first1 = HG | last2 = Flewett | first2 = TH | last3 = Candeias | first3 = JAN | last4 = Barth | first4 = OM | year = 1988 | title = A virus with a bisegmented double-stranded RNA genome in rat (Oryzomys nigripes) intestines | url = | journal = J Gen Virol | volume = 69 | issue = 11| pages = 2749–2754 | doi=10.1099/0022-1317-69-11-2749| pmid = 3053986 }} 5. ^{{cite journal | last1 = Smits | first1 = SL | last2 = van Leeuwen | first2 = M | last3 = Schapendonk | first3 = CM | last4 = Schürch | first4 = AC | last5 = Bodewes | first5 = R | last6 = Haagmans | first6 = BL | last7 = Osterhaus | first7 = AD | year = 2012 | title = Picobirnaviruses in the human respiratory tract | url = | journal = Emerg Infect Dis | volume = 18 | issue = 9| pages = 1539–40 | doi = 10.3201/eid1809.120507 | pmid = 22932227 | pmc = 3437736 }} 6. ^{{cite journal | last1 = Malik | first1 = YS | last2 = Kumar | first2 = N | last3 = Sharma | first3 = K | last4 = Dhama | first4 = K | last5 = Shabbir | first5 = MZ | last6 = Ganesh | first6 = B | last7 = Kobayashi | first7 = N | last8 = Banyai | first8 = K | year = 2014 | title = Epidemiology, phylogeny, and evolution of emerging enteric Picobirnaviruses of animal origin and their relationship to human strains | journal = Biomed Res. Int. | volume = 2014| issue = | pages = 1–13| doi = 10.1155/2014/780752 | pmid=25136620 | pmc=4124650}} External links
2 : Double-stranded RNA viruses|Riboviria |
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