“PIK3C2A”的意思、由来-开放百科全书

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of Class II PI 3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.^[2]

References

1. ^{{cite journal |vauthors=Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, Waterfield MD | title = Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin | journal = Biochem J | volume = 326 | issue = 1| pages = 139–47 |date=Nov 1997 | pmid = 9337861 | pmc = 1218647 | doi = 10.1042/bj3260139}}
2. ^¹{{cite web | title = Entrez Gene: PIK3C2A phosphoinositide-3-kinase, class 2, alpha polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5286| accessdate = }}

Further reading

{{cite journal | author=Lee C |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–682 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 |name-list-format=vanc| author2=Liu QH | author3=Tomkowicz B | display-authors=3 | last4=Yi | first4=Y | last5=Freedman | first5=BD | last6=Collman | first6=RG }}

{{cite journal | author=Milani D |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961–22964 |year= 1996 |pmid= 8798481 |doi=10.1074/jbc.271.38.22961 |name-list-format=vanc| author2=Mazzoni M | author3=Borgatti P | display-authors=3 | last4=Zauli | first4=G | last5=Cantley | first5=L | last6=Capitani | first6=S }}

{{cite journal |vauthors=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457–2465 |year= 1997 |pmid= 9341793 |doi=10.1002/eji.1830270946 }}

{{cite journal | author=Borgatti P |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805–2811 |year= 1998 |pmid= 9394803 |doi=10.1002/eji.1830271110 |name-list-format=vanc| author2=Zauli G | author3=Colamussi ML | display-authors=3 | last4=Gibellini | first4=Davide | last5=Previati | first5=Maurizio | last6=Cantley | first6=Lewis L. | last7=Capitani | first7=Silvano }}

{{cite journal |vauthors=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–337 |year= 1998 |pmid= 9446795 |doi=10.1006/bbrc.1997.7877 }}

{{cite journal | author=Zhang J |title=A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14081–14084 |year= 1998 |pmid= 9603905 |doi=10.1074/jbc.273.23.14081 |name-list-format=vanc| author2=Banfić H | author3=Straforini F | display-authors=3 | last4=Tosi | first4=L | last5=Volinia | first5=S | last6=Rittenhouse | first6=SE }}

{{cite journal | author=Milani D |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells |journal=AIDS |volume=12 |issue= 11 |pages= 1275–1284 |year= 1998 |pmid= 9708406 |doi=10.1097/00002030-199811000-00008 |name-list-format=vanc| author2=Mazzoni M | author3=Zauli G | display-authors=3 | last4=Mischiati | first4=Carlo | last5=Gibellini | first5=Davide | last6=Giacca | first6=Mauro | last7=Capitani | first7=Silvano }}

{{cite journal | author=Jauliac S |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183–3191 |year= 1998 |pmid= 9808187 |doi=10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A |name-list-format=vanc| author2=Mazerolles F | author3=Jabado N | display-authors=3 | last4=Pallier | first4=Annaïck | last5=Bernard | first5=Frédéric | last6=Peake | first6=Jane | last7=Fischer | first7=Alain | last8=Hivroz | first8=Claire }}

{{cite journal | author=Brown RA |title=Insulin activates the alpha isoform of class II phosphoinositide 3-kinase |journal=J. Biol. Chem. |volume=274 |issue= 21 |pages= 14529–14532 |year= 1999 |pmid= 10329640 |doi=10.1074/jbc.274.21.14529 |name-list-format=vanc| author2=Domin J | author3=Arcaro A | display-authors=3 | last4=Waterfield | first4=MD | last5=Shepherd | first5=PR }}

{{cite journal | author=Idriss H |title=HIV-1 reverse transcriptase is phosphorylated in vitro and in a cellular system |journal=Int. J. Biochem. Cell Biol. |volume=31 |issue= 12 |pages= 1443–1452 |year= 2000 |pmid= 10641798 |doi=10.1016/S1357-2725(99)00097-7 |name-list-format=vanc| author2=Kawa S | author3=Damuni Z | display-authors=3 | last4=Thompson | first4=EB | last5=Wilson | first5=SH }}

{{cite journal | author=Domin J |title=The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles |journal=J. Biol. Chem. |volume=275 |issue= 16 |pages= 11943–11950 |year= 2000 |pmid= 10766823 |doi=10.1074/jbc.275.16.11943 |name-list-format=vanc| author2=Gaidarov I | author3=Smith ME | display-authors=3 | last4=Keen | first4=JH | last5=Waterfield | first5=MD }}

{{cite journal | author=Arcaro A |title=Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3817–3830 |year= 2000 |pmid= 10805725 |doi=10.1128/MCB.20.11.3817-3830.2000 | pmc=85707 |name-list-format=vanc| author2=Zvelebil MJ | author3=Wallasch C | display-authors=3 | last4=Ullrich | first4=A. | last5=Waterfield | first5=M. D. | last6=Domin | first6=J. }}

{{cite journal |vauthors=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes |journal=Blood |volume=97 |issue= 2 |pages= 352–358 |year= 2001 |pmid= 11154208 |doi=10.1182/blood.V97.2.352 }}

{{cite journal | author=Zauli G |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–491 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com |name-list-format=vanc| author2=Milani D | author3=Mirandola P | display-authors=3 | last4=Mazzoni | first4=M | last5=Secchiero | first5=P | last6=Miscia | first6=S | last7=Capitani | first7=S }}

{{cite journal |vauthors=Gaidarov I, Smith ME, Domin J, Keen JH |title=The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking |journal=Mol. Cell |volume=7 |issue= 2 |pages= 443–449 |year= 2001 |pmid= 11239472 |doi=10.1016/S1097-2765(01)00191-5 }}

{{cite journal | author=Caldwell GM |title=Mapping of genes and transcribed sequences in a gene rich 400-kb region on human chromosome 11p15.1→p14 |journal=Cytogenet. Cell Genet. |volume=92 |issue= 1–2 |pages= 103–107 |year= 2001 |pmid= 11306805 |doi=10.1159/000056877 |name-list-format=vanc| author2=Eddy RL | author3=Day CD | display-authors=3 | last4=Haley | first4=L.H. | last5=Cooper | first5=P.R. | last6=Sait | first6=S.S.J. | last7=Hejtmancik | first7=F. | last8=Smith | first8=R.J.H. | last9=Morton | first9=C.C. }}

{{cite journal |vauthors=Didichenko SA, Thelen M |title=Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48135–42 |year= 2002 |pmid= 11606566 |doi= 10.1074/jbc.M104610200 }}

{{cite journal | author=Deregibus MC |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195–25202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200 |name-list-format=vanc| author2=Cantaluppi V | author3=Doublier S | display-authors=3 | last4=Brizzi | first4=MF | last5=Deambrosis | first5=I | last6=Albini | first6=A | last7=Camussi | first7=G }}

{{cite journal |vauthors=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254–60 |year= 2002 |pmid= 12077252 |doi= 10.4049/jimmunol.169.1.254}}

References

Further reading

External links