“PIK3C2B”的意思、由来-开放百科全书

Function

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmannin. The C2 domain of this protein was shown to bind phospholipids but not Ca²⁺, which suggests that this enzyme may function in a calcium-independent manner.^[3]

References

1. ^{{cite journal | vauthors = Brown RA, Ho LK, Weber-Hall SJ, Shipley JM, Fry MJ | title = Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K | journal = Biochemical and Biophysical Research Communications | volume = 233 | issue = 2 | pages = 537–44 | date = Apr 1997 | pmid = 9144573 | pmc = | doi = 10.1006/bbrc.1997.6495 }}
2. ^{{cite journal | vauthors = Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD | title = Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 49 | pages = 33082–90 | date = Dec 1998 | pmid = 9830063 | pmc = | doi = 10.1074/jbc.273.49.33082 }}
3. ^¹{{cite web | title = Entrez Gene: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5287| accessdate = }}

Further reading

{{cite journal | vauthors = Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG | title = Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways | journal = Journal of Leukocyte Biology | volume = 74 | issue = 5 | pages = 676–82 | date = Nov 2003 | pmid = 12960231 | doi = 10.1189/jlb.0503206 }}

{{cite journal | vauthors = Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H | title = Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo | journal = Oncogene | volume = 9 | issue = 10 | pages = 2991–8 | date = Oct 1994 | pmid = 8084603 | doi = }}

{{cite journal | vauthors = Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S | title = Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 38 | pages = 22961–4 | date = Sep 1996 | pmid = 8798481 | doi = 10.1074/jbc.271.38.22961 }}

{{cite journal | vauthors = Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H | title = The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase | journal = Oncogene | volume = 14 | issue = 25 | pages = 3067–72 | date = Jun 1997 | pmid = 9223670 | doi = 10.1038/sj.onc.1201153 }}

{{cite journal | vauthors = Mazerolles F, Barbat C, Fischer A | title = Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity | journal = European Journal of Immunology | volume = 27 | issue = 9 | pages = 2457–65 | date = Sep 1997 | pmid = 9341793 | doi = 10.1002/eji.1830270946 }}

{{cite journal | vauthors = Borgatti P, Zauli G, Colamussi ML, Gibellini D, Previati M, Cantley LL, Capitani S | title = Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells | journal = European Journal of Immunology | volume = 27 | issue = 11 | pages = 2805–11 | date = Nov 1997 | pmid = 9394803 | doi = 10.1002/eji.1830271110 }}

{{cite journal | vauthors = Borgatti P, Zauli G, Cantley LC, Capitani S | title = Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells | journal = Biochemical and Biophysical Research Communications | volume = 242 | issue = 2 | pages = 332–7 | date = Jan 1998 | pmid = 9446795 | doi = 10.1006/bbrc.1997.7877 }}

{{cite journal | vauthors = Milani D, Mazzoni M, Zauli G, Mischiati C, Gibellini D, Giacca M, Capitani S | title = HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells | journal = AIDS | volume = 12 | issue = 11 | pages = 1275–84 | date = Jul 1998 | pmid = 9708406 | doi = 10.1097/00002030-199811000-00008 }}

{{cite journal | vauthors = Jauliac S, Mazerolles F, Jabado N, Pallier A, Bernard F, Peake J, Fischer A, Hivroz C | title = Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity | journal = European Journal of Immunology | volume = 28 | issue = 10 | pages = 3183–91 | date = Oct 1998 | pmid = 9808187 | doi = 10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A }}

{{cite journal | vauthors = Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J | title = Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors | journal = Molecular and Cellular Biology | volume = 20 | issue = 11 | pages = 3817–30 | date = Jun 2000 | pmid = 10805725 | pmc = 85707 | doi = 10.1128/MCB.20.11.3817-3830.2000 }}

{{cite journal | vauthors = Park IW, Wang JF, Groopman JE | title = HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes | journal = Blood | volume = 97 | issue = 2 | pages = 352–8 | date = Jan 2001 | pmid = 11154208 | doi = 10.1182/blood.V97.2.352 }}

{{cite journal | vauthors = Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S | title = HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway | journal = FASEB Journal | volume = 15 | issue = 2 | pages = 483–91 | date = Feb 2001 | pmid = 11156964 | doi = 10.1096/fj.00-0354com }}

{{cite journal | vauthors = Wheeler M, Domin J | title = Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2 | journal = Molecular and Cellular Biology | volume = 21 | issue = 19 | pages = 6660–7 | date = Oct 2001 | pmid = 11533253 | pmc = 99811 | doi = 10.1128/MCB.21.19.6660-6667.2001 }}

{{cite journal | vauthors = Deregibus MC, Cantaluppi V, Doublier S, Brizzi MF, Deambrosis I, Albini A, Camussi G | title = HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 28 | pages = 25195–202 | date = Jul 2002 | pmid = 11994280 | doi = 10.1074/jbc.M200921200 }}

{{cite journal | vauthors = Cook JA, August A, Henderson AJ | title = Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism | journal = Journal of Immunology | volume = 169 | issue = 1 | pages = 254–60 | date = Jul 2002 | pmid = 12077252 | doi = 10.4049/jimmunol.169.1.254 }}

{{cite journal | vauthors = Arcaro A, Khanzada UK, Vanhaesebroeck B, Tetley TD, Waterfield MD, Seckl MJ | title = Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation | journal = The EMBO Journal | volume = 21 | issue = 19 | pages = 5097–108 | date = Oct 2002 | pmid = 12356726 | pmc = 129034 | doi = 10.1093/emboj/cdf512 }}

{{cite journal | vauthors = Visnjić D, Crljen V, Curić J, Batinić D, Volinia S, Banfić H | title = The activation of nuclear phosphoinositide 3-kinase C2beta in all-trans-retinoic acid-differentiated HL-60 cells | journal = FEBS Letters | volume = 529 | issue = 2–3 | pages = 268–74 | date = Oct 2002 | pmid = 12372612 | doi = 10.1016/S0014-5793(02)03357-4 }}