请输入您要查询的百科知识:

 

词条 PIK3C2G
释义

  1. References

  2. Further reading

{{Infobox_gene}}Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.[2]
}}

References

1. ^{{cite journal |vauthors=Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ | title = cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12 | journal = Genomics | volume = 54 | issue = 3 | pages = 569–74 |date=Feb 1999 | pmid = 9878262 | pmc = | doi = 10.1006/geno.1998.5621 }}
2. ^{{cite web | title = Entrez Gene: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5288| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | author=Lee C |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 |name-list-format=vanc| author2=Liu QH | author3=Tomkowicz B | display-authors=3 | last4=Yi | first4=Y | last5=Freedman | first5=BD | last6=Collman | first6=RG }}
  • {{cite journal | author=Milani D |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961–4 |year= 1996 |pmid= 8798481 |doi=10.1074/jbc.271.38.22961 |name-list-format=vanc| author2=Mazzoni M | author3=Borgatti P | display-authors=3 | last4=Zauli | first4=G | last5=Cantley | first5=L | last6=Capitani | first6=S }}
  • {{cite journal |vauthors=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457–65 |year= 1997 |pmid= 9341793 |doi=10.1002/eji.1830270946 }}
  • {{cite journal | author=Borgatti P |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805–11 |year= 1998 |pmid= 9394803 |doi=10.1002/eji.1830271110 |name-list-format=vanc| author2=Zauli G | author3=Colamussi ML | display-authors=3 | last4=Gibellini | first4=Davide | last5=Previati | first5=Maurizio | last6=Cantley | first6=Lewis L. | last7=Capitani | first7=Silvano }}
  • {{cite journal |vauthors=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–7 |year= 1998 |pmid= 9446795 |doi=10.1006/bbrc.1997.7877 }}
  • {{cite journal | author=Misawa H |title=Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 2 |pages= 531–9 |year= 1998 |pmid= 9514948 |doi= 10.1006/bbrc.1998.8294 |name-list-format=vanc| author2=Ohtsubo M | author3=Copeland NG | display-authors=3 | last4=Gilbert | first4=Debra J. | last5=Jenkins | first5=Nancy A. | last6=Yoshimura | first6=Akihiko }}
  • {{cite journal | author=Ono F |title=A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7731–6 |year= 1998 |pmid= 9516481 |doi=10.1074/jbc.273.13.7731 |name-list-format=vanc| author2=Nakagawa T | author3=Saito S | display-authors=3 | last4=Owada | first4=Y | last5=Sakagami | first5=H | last6=Goto | first6=K | last7=Suzuki | first7=M | last8=Matsuno | first8=S | last9=Kondo | first9=H }}
  • {{cite journal | author=Milani D |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells |journal=AIDS |volume=12 |issue= 11 |pages= 1275–84 |year= 1998 |pmid= 9708406 |doi=10.1097/00002030-199811000-00008 |name-list-format=vanc| author2=Mazzoni M | author3=Zauli G | display-authors=3 | last4=Mischiati | first4=Carlo | last5=Gibellini | first5=Davide | last6=Giacca | first6=Mauro | last7=Capitani | first7=Silvano }}
  • {{cite journal | author=Jauliac S |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183–91 |year= 1998 |pmid= 9808187 |doi=10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A |name-list-format=vanc| author2=Mazerolles F | author3=Jabado N | display-authors=3 | last4=Pallier | first4=Annaïck | last5=Bernard | first5=Frédéric | last6=Peake | first6=Jane | last7=Fischer | first7=Alain | last8=Hivroz | first8=Claire }}
  • {{cite journal |vauthors=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes |journal=Blood |volume=97 |issue= 2 |pages= 352–8 |year= 2001 |pmid= 11154208 |doi=10.1182/blood.V97.2.352 }}
  • {{cite journal | author=Zauli G |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com |name-list-format=vanc| author2=Milani D | author3=Mirandola P | display-authors=3 | last4=Mazzoni | first4=M | last5=Secchiero | first5=P | last6=Miscia | first6=S | last7=Capitani | first7=S }}
  • {{cite journal | author=Deregibus MC |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195–202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200 |name-list-format=vanc| author2=Cantaluppi V | author3=Doublier S | display-authors=3 | last4=Brizzi | first4=MF | last5=Deambrosis | first5=I | last6=Albini | first6=A | last7=Camussi | first7=G }}
  • {{cite journal |vauthors=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254–60 |year= 2002 |pmid= 12077252 |doi= 10.4049/jimmunol.169.1.254}}
  • {{cite journal |vauthors=François F, Klotman ME |title=Phosphatidylinositol 3-Kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages |journal=J. Virol. |volume=77 |issue= 4 |pages= 2539–49 |year= 2003 |pmid= 12551992 |doi=10.1128/JVI.77.4.2539-2549.2003 | pmc=141101 }}
  • {{cite journal |vauthors=Khan NA, Di Cello F, Nath A, Kim KS |title=Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells |journal=J. Neurovirol. |volume=9 |issue= 6 |pages= 584–93 |year= 2004 |pmid= 14602571 |doi=10.1080/jnv.9.6.584.593 }}
  • {{cite journal | author=Langford D |title=Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120 |journal=BMC Neuroscience |volume=6 |pages= 8 |year= 2006 |pmid= 15689238 |doi= 10.1186/1471-2202-6-8 | pmc=549045 |name-list-format=vanc| author2=Hurford R | author3=Hashimoto M | display-authors=3 | last4=Digicaylioglu | first4=Murat | last5=Masliah | first5=Eliezer }}
  • {{cite journal |vauthors=Lee C, Tomkowicz B, Freedman BD, Collman RG |title=HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways. |journal=J. Leukoc. Biol. |volume=78 |issue= 4 |pages= 1016–23 |year= 2006 |pmid= 16081599 |doi= 10.1189/jlb.0105056 }}
  • {{cite journal |vauthors=Anand AR, Ganju RK |title=HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45 |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12289–99 |year= 2006 |pmid= 16524887 |doi= 10.1074/jbc.M511786200 }}
{{refend}}{{gene-12-stub}}
随便看

 

开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。

 

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间:2024/11/13 20:32:03