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词条 PIK3CB
释义

  1. References

  2. Further reading

{{Underlinked|date=June 2016}}{{Infobox_gene}}Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.[1][2]

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM][2]

References

1. ^{{cite journal | vauthors = Hu P, Mondino A, Skolnik EY, Schlessinger J | title = Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85 | journal = Mol Cell Biol | volume = 13 | issue = 12 | pages = 7677–88 |date=Jan 1994 | pmid = 8246984 | pmc = 364839 | doi = }}
2. ^1 {{cite web | title = Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5291| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Katada T, Kurosu H, Okada T, etal |title=Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors. |journal=Chem. Phys. Lipids |volume=98 |issue= 1-2 |pages= 79–86 |year= 1999 |pmid= 10358930 |doi=10.1016/S0009-3084(99)00020-1 }}
  • {{cite journal |vauthors=Lee C, Liu QH, Tomkowicz B, etal |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 }}
  • {{cite journal |vauthors=Carpenter CL, Duckworth BC, Auger KR, etal |title=Purification and characterization of phosphoinositide 3-kinase from rat liver. |journal=J. Biol. Chem. |volume=265 |issue= 32 |pages= 19704–11 |year= 1991 |pmid= 2174051 |doi= }}
  • {{cite journal |vauthors=Bonnefoy-Bérard N, Liu YC, von Willebrand M, etal |title=Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10142–6 |year= 1995 |pmid= 7479742 |doi=10.1073/pnas.92.22.10142 | pmc=40752 }}
  • {{cite journal | vauthors=Hu P, Schlessinger J |title=Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2577–83 |year= 1994 |pmid= 8139559 |doi= 10.1128/mcb.14.4.2577| pmc=358625 }}
  • {{cite journal |vauthors=Milani D, Mazzoni M, Borgatti P, etal |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961–4 |year= 1996 |pmid= 8798481 |doi=10.1074/jbc.271.38.22961 }}
  • {{cite journal | vauthors=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457–65 |year= 1997 |pmid= 9341793 |doi=10.1002/eji.1830270946 }}
  • {{cite journal |vauthors=Borgatti P, Zauli G, Colamussi ML, etal |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805–11 |year= 1998 |pmid= 9394803 |doi=10.1002/eji.1830271110 }}
  • {{cite journal | vauthors=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–7 |year= 1998 |pmid= 9446795 |doi=10.1006/bbrc.1997.7877 }}
  • {{cite journal |vauthors=Milani D, Mazzoni M, Zauli G, etal |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275–84 |year= 1998 |pmid= 9708406 |doi=10.1097/00002030-199811000-00008 }}
  • {{cite journal |vauthors=Jauliac S, Mazerolles F, Jabado N, etal |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183–91 |year= 1998 |pmid= 9808187 |doi=10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A }}
  • {{cite journal |vauthors=Graness A, Adomeit A, Heinze R, etal |title=A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 32016–22 |year= 1998 |pmid= 9822674 |doi=10.1074/jbc.273.48.32016 }}
  • {{cite journal | vauthors=Sotsios Y, Whittaker GC, Westwick J, Ward SG |title=The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes. |journal=J. Immunol. |volume=163 |issue= 11 |pages= 5954–63 |year= 1999 |pmid= 10570282 |doi= }}
  • {{cite journal | vauthors=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352–8 |year= 2001 |pmid= 11154208 |doi=10.1182/blood.V97.2.352 }}
  • {{cite journal |vauthors=Zauli G, Milani D, Mirandola P, etal |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
  • {{cite journal | vauthors=Yang H, Wang X, Raizada MK |title=Characterization of signal transduction pathway in neurotropic action of angiotensin II in brain neurons. |journal=Endocrinology |volume=142 |issue= 8 |pages= 3502–11 |year= 2001 |pmid= 11459796 |doi=10.1210/en.142.8.3502 }}
  • {{cite journal | vauthors=Steták A, Csermely P, Ullrich A, Kéri G |title=Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 3 |pages= 564–72 |year= 2001 |pmid= 11676480 |doi= 10.1006/bbrc.2001.5811 }}
  • {{cite journal |vauthors=Ueki K, Yballe CM, Brachmann SM, etal |title=Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 419–24 |year= 2002 |pmid= 11752399 |doi= 10.1073/pnas.012581799 | pmc=117575 }}
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