| 释义 |
- References
- Further reading
{{about|the protein encoded by the PKIA gene in humans|the military casualty classification|Killed in action}}{{Underlinked|date=March 2014}}{{Infobox_gene}}cAMP-dependent protein kinase inhibitor alpha is a protein that in humans is encoded by the PKIA gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.[2]
}}References1. ^{{cite journal | vauthors = Olsen SR, Uhler MD | title = Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor | journal = Mol Endocrinol | volume = 5 | issue = 9 | pages = 1246–56 |date=Feb 1992 | pmid = 1770951 | pmc = | doi =10.1210/mend-5-9-1246 }}
2. ^1 {{cite web | title = Entrez Gene: PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5569| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Olsen SR, Uhler MD |title=Isolation and characterization of cDNA clones for an inhibitor protein of cAMP-dependent protein kinase |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11158–62 |year= 1991 |pmid= 1710219 |doi= }}
- {{cite journal |vauthors=Knighton DR, Zheng JH, Ten Eyck LF, etal |title=Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase |journal=Science |volume=253 |issue= 5018 |pages= 414–20 |year= 1991 |pmid= 1862343 |doi=10.1126/science.1862343 }}
- {{cite journal | vauthors=Van Patten SM, Heisermann GJ, Cheng HC, Walsh DA |title=Tyrosine kinase catalyzed phosphorylation and inactivation of the inhibitor protein of the cAMP-dependent protein kinase |journal=J. Biol. Chem. |volume=262 |issue= 7 |pages= 3398–403 |year= 1987 |pmid= 2434500 |doi= }}
- {{cite journal | vauthors=Scott JD, Fischer EH, Demaille JG, Krebs EG |title=Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 13 |pages= 4379–83 |year= 1985 |pmid= 2989819 |doi=10.1073/pnas.82.13.4379 | pmc=390417 }}
- {{cite journal | vauthors=Scott JD, Glaccum MB, Fischer EH, Krebs EG |title=Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 6 |pages= 1613–6 |year= 1986 |pmid= 3456605 |doi=10.1073/pnas.83.6.1613 | pmc=323133 }}
- {{cite journal | vauthors=Wen W, Taylor SS, Meinkoth JL |title=The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2041–6 |year= 1995 |pmid= 7836431 |doi=10.1074/jbc.270.5.2041 }}
- {{cite journal |vauthors=Baude EJ, Dignam SS, Olsen SR, etal |title=Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2316–23 |year= 1994 |pmid= 7905001 |doi= }}
- {{cite journal | vauthors=Baude EJ, Dignam SS, Reimann EM, Uhler MD |title=Evidence for the importance of hydrophobic residues in the interactions between the cAMP-dependent protein kinase catalytic subunit and the protein kinase inhibitors |journal=J. Biol. Chem. |volume=269 |issue= 27 |pages= 18128–33 |year= 1994 |pmid= 8027074 |doi= }}
- {{cite journal | vauthors=Fritz CC, Green MR |title=HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 848–54 |year= 1997 |pmid= 8805303 |doi=10.1016/S0960-9822(02)00608-5 }}
- {{cite journal |vauthors=Zimmermann B, Chiorini JA, Ma Y, etal |title=PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5370–8 |year= 1999 |pmid= 10026146 |doi=10.1074/jbc.274.9.5370 }}
- {{cite journal |vauthors=Yu J, Yu L, Chen Z, etal |title=Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors |journal=Brain Res. Mol. Brain Res. |volume=99 |issue= 2 |pages= 145–9 |year= 2002 |pmid= 11978406 |doi=10.1016/S0169-328X(02)00104-3 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Gassel M, Breitenlechner CB, Rüger P, etal |title=Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT) |journal=J. Mol. Biol. |volume=329 |issue= 5 |pages= 1021–34 |year= 2003 |pmid= 12798691 |doi=10.1016/S0022-2836(03)00518-7 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
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