释义 |
- Interactions
- Further reading
- References
{{Infobox_gene}}Serine/threonine-protein kinase N2 is an enzyme that in humans is encoded by the PKN2 gene.[1][2][3] Interactions PKN2 has been shown to interact with: {{div col|colwidth=20em}}- AKT1,[4]
- NCK1,[5][6]
- PTPN13,[7]
- Phosphoinositide-dependent kinase-1,[8][9] and
- RHOA.[5][10]
{{Div col end}} Further reading {{refbegin | 2}}- {{cite journal | vauthors = Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, Jenkins NA, Gilbert DJ, Copeland NG, Der CJ | title = Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling | journal = J. Biol. Chem. | volume = 271 | issue = 46 | pages = 28772–28776 | year = 1997 | pmid = 8910519 | doi = 10.1074/jbc.271.46.28772 }}
- {{cite journal | vauthors = Yu W, Liu J, Morrice NA, Wettenhall RE | title = Isolation and characterization of a structural homologue of human PRK2 from rat liver. Distinguishing substrate and lipid activator specificities | journal = J. Biol. Chem. | volume = 272 | issue = 15 | pages = 10030–10034 | year = 1997 | pmid = 9092545 | doi = 10.1074/jbc.272.15.10030 }}
- {{cite journal | vauthors = Vincent S, Settleman J | title = The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 2247–56 | year = 1997 | pmid = 9121475 | pmc = 232074 | doi = 10.1128/MCB.17.4.2247}}
- {{cite journal | vauthors = Cryns VL, Byun Y, Rana A, Mellor H, Lustig KD, Ghanem L, Parker PJ, Kirschner MW, Yuan J | title = Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy | journal = J. Biol. Chem. | volume = 272 | issue = 47 | pages = 29449–29453 | year = 1997 | pmid = 9368003 | doi = 10.1074/jbc.272.47.29449 }}
- {{cite journal | vauthors = Braverman LE, Quilliam LA | title = Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck | journal = J. Biol. Chem. | volume = 274 | issue = 9 | pages = 5542–5549 | year = 1999 | pmid = 10026169 | doi = 10.1074/jbc.274.9.5542 }}
- {{cite journal | vauthors = Flynn P, Mellor H, Casamassima A, Parker PJ | title = Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase | journal = J. Biol. Chem. | volume = 275 | issue = 15 | pages = 11064–11070 | year = 2000 | pmid = 10753910 | doi = 10.1074/jbc.275.15.11064 }}
- {{cite journal | vauthors = Sun W, Vincent S, Settleman J, Johnson GL | title = MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase | journal = J. Biol. Chem. | volume = 275 | issue = 32 | pages = 24421–24428 | year = 2000 | pmid = 10818102 | doi = 10.1074/jbc.M003148200 }}
- {{cite journal | vauthors = Koh H, Lee KH, Kim D, Kim S, Kim JW, Chung J | title = Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage | journal = J. Biol. Chem. | volume = 275 | issue = 44 | pages = 34451–34458 | year = 2000 | pmid = 10926925 | doi = 10.1074/jbc.M001753200 }}
- {{cite journal | vauthors = Gross C, Heumann R, Erdmann KS | title = The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif | journal = FEBS Lett. | volume = 496 | issue = 2–3 | pages = 101–104 | year = 2001 | pmid = 11356191 | doi = 10.1016/S0014-5793(01)02401-2 }}
- {{cite journal | vauthors = Hodgkinson CP, Sale GJ | title = Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment | journal = Biochemistry | volume = 41 | issue = 2 | pages = 561–569 | year = 2002 | pmid = 11781095 | doi = 10.1021/bi010719z }}
- {{cite journal | vauthors = McDonald C, Vacratsis PO, Bliska JB, Dixon JE | title = The yersinia virulence factor YopM forms a novel protein complex with two cellular kinases | journal = J. Biol. Chem. | volume = 278 | issue = 20 | pages = 18514–18523 | year = 2003 | pmid = 12626518 | doi = 10.1074/jbc.M301226200 }}
- {{cite journal | vauthors = Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A | title = The human plasma proteome: a nonredundant list developed by combination of four separate sources | journal = Mol. Cell. Proteomics | volume = 3 | issue = 4 | pages = 311–326 | year = 2004 | pmid = 14718574 | doi = 10.1074/mcp.M300127-MCP200 }}
- {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–12135 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
- {{cite journal | vauthors = Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ | title = Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor | journal = Chem. Biol. | volume = 12 | issue = 3 | pages = 385–395 | year = 2005 | pmid = 15797222 | doi = 10.1016/j.chembiol.2005.01.015 }}
- {{cite journal | vauthors = DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A | title = Phosphoproteomic analysis of synaptosomes from human cerebral cortex | journal = J. Proteome Res. | volume = 4 | issue = 2 | pages = 306–315 | year = 2005 | pmid = 15822905 | doi = 10.1021/pr0498436 }}
- {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
{{refend}}References1. ^{{cite journal | vauthors = Palmer RH, Ridden J, Parker PJ | title = Identification of multiple, novel, protein kinase C-related gene products | journal = FEBS Lett | volume = 356 | issue = 1 | pages = 5–8 | date = January 1995 | pmid = 7988719 | pmc = | doi = 10.1016/0014-5793(94)01202-4 }} 2. ^{{cite journal | vauthors = Palmer RH, Ridden J, Parker PJ | title = Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family | journal = Eur J Biochem | volume = 227 | issue = 1–2 | pages = 344–351 | date = March 1995 | pmid = 7851406 | pmc = | doi = 10.1111/j.1432-1033.1995.tb20395.x }} 3. ^{{cite web | title = Entrez Gene: PKN2 protein kinase N2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5586| accessdate = }} 4. ^{{cite journal | vauthors = Koh H, Lee KH, Kim D, Kim S, Kim JW, Chung J | title = Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage | journal = J. Biol. Chem. | volume = 275 | issue = 44 | pages = 34451–8 | date = November 2000 | pmid = 10926925 | doi = 10.1074/jbc.M001753200 }} 5. ^1 {{cite journal | vauthors = Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, Jenkins NA, Gilbert DJ, Copeland NG, Der CJ | title = Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling | journal = J. Biol. Chem. | volume = 271 | issue = 46 | pages = 28772–6 | date = November 1996 | pmid = 8910519 | doi = 10.1074/jbc.271.46.28772}} 6. ^{{cite journal | vauthors = Braverman LE, Quilliam LA | title = Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck | journal = J. Biol. Chem. | volume = 274 | issue = 9 | pages = 5542–9 | date = February 1999 | pmid = 10026169 | doi = 10.1074/jbc.274.9.5542}} 7. ^{{cite journal | vauthors = Gross C, Heumann R, Erdmann KS | title = The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif | journal = FEBS Lett. | volume = 496 | issue = 2–3 | pages = 101–4 | date = May 2001 | pmid = 11356191 | doi = 10.1016/s0014-5793(01)02401-2}} 8. ^{{cite journal | vauthors = Hodgkinson CP, Sale GJ | title = Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment | journal = Biochemistry | volume = 41 | issue = 2 | pages = 561–9 | date = January 2002 | pmid = 11781095 | doi = 10.1021/bi010719z}} 9. ^{{cite journal | vauthors = Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR | title = A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1 | journal = J. Biol. Chem. | volume = 275 | issue = 27 | pages = 20806–13 | date = July 2000 | pmid = 10764742 | doi = 10.1074/jbc.M000421200 }} 10. ^{{cite journal | vauthors = Flynn P, Mellor H, Palmer R, Panayotou G, Parker PJ | title = Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif | journal = J. Biol. Chem. | volume = 273 | issue = 5 | pages = 2698–705 | date = January 1998 | pmid = 9446575 | doi = 10.1074/jbc.273.5.2698}}
{{Serine/threonine-specific protein kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-1-stub}} 1 : EC 2.7.11 |