PKU can refer to:

• Phenylketonuria, a genetic disease
• Peking University, Beijing, China
• Pku, an Armenian musical instrument
• Sultan Syarif Kasim II International Airport, Pekanbaru, Riau, Indonesia, IATA code

• Association of Waterways Cruising Clubs
• Association of waterways cruising clubs
• Association of western pulp and paper workers
• Association of Western Pulp and Paper Workers
• Association of Women's Health, Obstetric and Neonatal Nurses
• Association of women solicitors
• Association of Women Victims of War
• Association of Writers and Artists of Albania
• Association of Wrongdoers
• Association Of Wrongdoers
• Association of xaintois communes
• Association of Xaintois communes
• Association of Yale Alumni
• Association of Young Legal Historians
• Association of Youth Organizations Nepal
• Association on American Indian Affairs
• Association (organization)
• Association Park (Cincinnati)
• Association pour défendre la mémoire du maréchal Pétain
• Association President
• Association quebecoise de linguistique
• Association Royale des Radio-Amateurs du Maroc
• Association royale des radio amateurs du maroc
• Association Royale des Radio Amateurs du Maroc
• Association Sale