Luis Castillo may refer to:

• Luis Castillo (American football), defensive end
• Luis Castillo (second baseman), Major League Baseball second baseman
• Luis Castillo (pitcher), Major League Baseball pitcher
• Luis Castillo (boxer), boxer from Mexico
• Luis Castillo (Ecuadorian boxer), boxer from Ecuador
• Luis Castillo (musician), keyboard player and backup vocalist for American rock band P.O.D.
• Luís Leandro Castillo, Argentine footballer

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