| 释义 |
- References
- Further reading
{{Infobox_gene}}Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.[1][2]This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.[2] In some studies, the PLXNA2 gene is associated with schizophrenia.[3] and anxiety.[4] References1. ^{{cite journal | vauthors = Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM | title = A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor | journal = Proc Natl Acad Sci USA | volume = 93 | issue = 2 | pages = 674–8 |date=Mar 1996 | pmid = 8570614 | pmc = 40111 | doi =10.1073/pnas.93.2.674 }}
2. ^1 {{cite web | title = Entrez Gene: PLXNA2 plexin A2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5362| accessdate = }}
3. ^Gene Overview of All Published Schizophrenia-Association Studies for PLXNA2 {{webarchive|url=https://web.archive.org/web/20090221130511/http://schizophreniaforum.org/res/sczgene/geneoverview.asp?geneid=259 |date=2009-02-21 }} - база данных SZGene, сайт Schizophrenia Research Forum
4. ^{{cite journal |vauthors=Wray NR, James MR, Mah SP, Nelson M, Andrews G, Sullivan PF, Montgomery GW, Birley AJ, Braun A, Martin NG |title=Anxiety and comorbid measures associated with PLXNA2 |journal=Arch. Gen. Psychiatry |volume=64 |issue=3 |pages=318–26 |date=March 2007 |pmid=17339520 |doi=10.1001/archpsyc.64.3.318 |url=http://archpsyc.ama-assn.org/cgi/pmidlookup?view=long&pmid=17339520 }}{{dead link|date=March 2018 |bot=InternetArchiveBot |fix-attempted=yes }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Negishi M, Oinuma I, Katoh H |title=Plexins: axon guidance and signal transduction |journal=Cell. Mol. Life Sci. |volume=62 |issue= 12 |pages= 1363–71 |year= 2005 |pmid= 15818466 |doi= 10.1007/s00018-005-5018-2 }}
- {{cite journal |vauthors=Seki N, Ohira M, Nagase T, etal |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=10.1093/dnares/4.5.345 }}
- {{cite journal |vauthors=Tamagnone L, Artigiani S, Chen H, etal |title=Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates |journal=Cell |volume=99 |issue= 1 |pages= 71–80 |year= 1999 |pmid= 10520995 |doi=10.1016/S0092-8674(00)80063-X }}
- {{cite journal | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Mah S, Nelson MR, Delisi LE, etal |title=Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia |journal=Mol. Psychiatry |volume=11 |issue= 5 |pages= 471–8 |year= 2006 |pmid= 16402134 |doi= 10.1038/sj.mp.4001785 }}
- {{cite journal |vauthors=Fujii T, Iijima Y, Kondo H, etal |title=Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population |journal=Prog. Neuropsychopharmacol. Biol. Psychiatry |volume=31 |issue= 4 |pages= 873–7 |year= 2007 |pmid= 17346868 |doi= 10.1016/j.pnpbp.2007.01.027 }}
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