“Polynucleotide 3'-phosphatase”的意思、由来-开放百科全书

词条

Polynucleotide 3'-phosphatase

释义

Structural studies
References

{{enzyme
| Name = polynucleotide 3'-phosphatase
| EC_number = 3.1.3.32
| CAS_number = 37288-16-7
| IUBMB_EC_number = 3/1/3/32
| GO_code = 0046403
| image =
| width =
| caption =
}}

In enzymology, a polynucleotide 3'-phosphatase ({{EC number|3.1.3.32}}) is an enzyme that catalyzes the chemical reaction

a 3'-phosphopolynucleotide + H₂O a polynucleotide + phosphate

Thus, the two substrates of this enzyme are 3'-phosphopolynucleotide and H₂O, whereas its two products are polynucleotide and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is polynucleotide 3'-phosphohydrolase. Other names in common use include 2'(3')-polynucleotidase, DNA 3'-phosphatase, deoxyribonucleate 3'-phosphatase, and 5'-polynucleotidekinase 3'-phosphatase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1UJX}} and {{PDB link|2BRF}}.

References

{{cite journal |vauthors=Becker A, Hurwitz J | date = 1967 | title = The enzymatic cleavage of phosphate termini from polynucleotides | journal = J. Biol. Chem. | volume = 242 | pages = 936–50 | pmid = 4289819 | issue = 5 }}

2 : EC 3.1.3|Enzymes of known structure

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