Luis Santos may refer to:

• Luís Capoulas Santos (born 1951), Portuguese politician
• Luis Santos (baseball) (born 1991), Dominican baseball player
• Luís Santos (chess player) (born 1955), Portuguese chess player
• Luís Santos (fighter) (born 1980), Brazilian mixed martial artist
• Luís Santos (water polo) (born 1980), Brazilian water polo player
• Luis Martín-Santos (1924–1964), Spanish psychiatrist and author

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