| 词条 | Ponazuril |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 448092475 | IUPAC_name = 1-Methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione | image = Ponazuril.png | tradename = Marquis | Drugs.com = {{drugs.com|pro|marquis}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Rx-only | legal_status = Veterinary use only | routes_of_administration = Oral | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 69004-04-2 | ATCvet = yes | ATC_prefix = P51 | ATC_suffix = AJ04 | ATC_supplemental = | PubChem = 3050408 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 2312474 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = JPW84AS66U | chemical_formula = | C=18 | H=14 | F=3 | N=3 | O=6 | S=1 | molecular_weight = 457.380 g/mol | smiles = CC1=C(C=CC(=C1)N2C(=O)NC(=O)N(C2=O)C)OC3=CC=C(C=C3)S(=O)(=O)C(F)(F)F | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = VBUNOIXRZNJNAD-UHFFFAOYSA-N }} Ponazuril (INN), sold by Merial, Inc.[1], now part of Boehringer Ingelheim[2], under the trade name Marquis® (15% w/w ponazuril), is a drug currently approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by Sarcocystis neurona.[3][4] More recently, veterinarians have been preparing a formulary version of the medication for use in small animals such as cats, dogs, and rabbits against coccidia, an intestinal parasite. Coccidia treatment is far shorter than treatment for EPM. See also
References1. ^{{Cite web|url=http://merial.com/en/content-pages/press-releases/merial-acquires-two-major-equine-health-products-from-bayer|title=Merial Aquires LEGEND® and MARQUIS® {{!}} Boehringer Ingelheim|website=merial.com|language=en|access-date=2018-04-30}} {{antiinfective-drug-stub}}{{Veterinary-med-stub}}2. ^{{Cite web|url=https://www.boehringer-ingelheim.com/press-release/sanofi-and-boehringer-ingelheim-confirm-closing-business-swap-january-1st-2017|title=Sanofi and Boehringer Ingelheim confirm Closing of business swap {{!}} www.boehringer-ingelheim.com|website=boehringer-ingelheim.com|language=en|access-date=2018-04-30}} 3. ^Marquis {{drugs.com|pro|marquis}} 4. ^{{Cite journal | last1 = MacKay | first1 = R. J. | last2 = Tanhauser | first2 = S. T. | last3 = Gillis | first3 = K. D. | last4 = Mayhew | first4 = I. G. | last5 = Kennedy | first5 = T. J. | title = Effect of intermittent oral administration of ponazuril on experimentalSarcocystis neuronainfection of horses | doi = 10.2460/ajvr.69.3.396 | journal = American Journal of Veterinary Research | volume = 69 | issue = 3 | pages = 396–402 | year = 2008 | pmid = 18312139 | pmc = }} 5 : Equine medications|Phenol ethers|Sulfones|Trifluoromethyl compounds|Triketones |
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