| 词条 | Lymphangiogenesis |
| 释义 |
|Name = Lympangiogenesis |Latin = |Image = |Caption = }}Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels[1] in a method believed to be similar to angiogenesis (blood vessel development).[2] Lymphangiogenesis plays an important physiological role in homeostasis, metabolism and immunity. Impaired or excessive lymphatic vessel formation has been implicated in a number of pathological conditions including neoplasm metastasis,[3] oedema, rheumatoid arthritis, psoriasis, lymphangiomatosis and impaired wound healing. The role of the lymphatic system in these diseases has received renewed interest largely due to the relevantly recent{{When|date=September 2017}} discovery of LEC (lymphatic endothelial cell)-specific markers such as podoplanin, LYVE-1, PROX-1, desmoplakin and VEGF-C receptor VEGFR-3[4]. These specific markers have enabled new insights into functional and molecular lymphatic biology. There are several known pro-lymphangiogenesis inducers such as VEGF-C, hyaluronic acid and ephrin-B2. Various mechanisms have been proposed to explain VEGFC patterning during lymphangiogenesis, including formation of Turing patterns.[5][6] References1. ^{{cite journal |author1=Michael Jeltsch |author2=Tuomas Tammela |author3=Kari Alitalo |author4=Jörg Wilting | title=Genesis and pathogenesis of lymphatic vessels | year= 2003 | journal=Cell and Tissue Research | volume= 314 | issue=1 | pages=69–84 | doi=10.1007/s00441-003-0777-2|pmid=12942362 }} 2. ^{{cite web |title=Lymphatic vasculature development |url=http://www.columbia.edu/itc/hs/medical/humandev/2009/HD18/Lymphatic.pdf |accessdate=17 December 2018}} 3. ^{{cite book|author=Steven A. Stacker|title=Lymphangiogenesis in Cancer Metastasis|url=https://books.google.com/books?id=oIIB9NIAwFoC&pg=PA27|accessdate=26 June 2010|date=1 July 2009|publisher=Springer|isbn=978-90-481-2246-2|pages=27–}} 4. ^{{Cite journal|last=Jha|first=Sawan K.|last2=Rauniyar|first2=Khushbu|last3=Jeltsch|first3=Michael|date=2018|title=Key molecules in lymphatic development, function, and identification|journal=Annals of Anatomy - Anatomischer Anzeiger|volume=219|pages=25–34|doi=10.1016/j.aanat.2018.05.003|pmid=29842991}} 5. ^{{Cite journal|last=Wertheim|first=Kenneth Y.|last2=Roose|first2=Tiina|date=April 2017|title=A Mathematical Model of Lymphangiogenesis in a Zebrafish Embryo|journal=Bulletin of Mathematical Biology|volume=79|issue=4|pages=693–737|doi=10.1007/s11538-017-0248-7|issn=1522-9602|pmc=5501200|pmid=28233173}} 6. ^{{Cite journal|last=Roose|first=Tiina|last2=Wertheim|first2=Kenneth Y.|date=2019-01-03|title=Can VEGFC Form Turing Patterns in the Zebrafish Embryo?|journal=Bulletin of Mathematical Biology|language=en|pages=1–37|doi=10.1007/s11538-018-00560-2|pmid=30607882|issn=1522-9602}} Further reading
1 : Lymphatic system |
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