| 释义 |
- References
- Further reading
{{Infobox_gene}}Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.[3]
}}References1. ^{{cite journal |vauthors=Horowitz DS, Kobayashi R, Krainer AR | title = A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs | journal = RNA | volume = 3 | issue = 12 | pages = 1374–87 |date=Dec 1997 | pmid = 9404889 | pmc = 1369579 | doi = }}
2. ^{{cite journal |vauthors=Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R | title = The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins | journal = RNA | volume = 4 | issue = 2 | pages = 127–41 |date=May 1998 | pmid = 9570313 | pmc = 1369602 | doi = }}
3. ^1 {{cite web | title = Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10465| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=Reidt U |title=Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7439–42 |year= 2000 |pmid= 10713041 |doi=10.1074/jbc.275.11.7439 |name-list-format=vanc| author2=Reuter K | author3=Achsel T | display-authors=3 | last4=Ingelfinger | first4=D | last5=Lührmann | first5=R | last6=Ficner | first6=R |url=http://pubman.mpdl.mpg.de/pubman/item/escidoc:600339/component/escidoc:2224255/600339.pdf}}
- {{cite journal |vauthors=Horowitz DS, Lee EJ, Mabon SA, Misteli T |title=A cyclophilin functions in pre-mRNA splicing |journal=EMBO J. |volume=21 |issue= 3 |pages= 470–80 |year= 2002 |pmid= 11823439 |doi=10.1093/emboj/21.3.470 | pmc=125845 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
- {{cite journal | author=Reidt U |title=Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide |journal=J. Mol. Biol. |volume=331 |issue= 1 |pages= 45–56 |year= 2003 |pmid= 12875835 |doi=10.1016/S0022-2836(03)00684-3 |name-list-format=vanc| author2=Wahl MC | author3=Fasshauer D | display-authors=3 | last4=Horowitz | first4=David S. | last5=Lührmann | first5=Reinhard | last6=Ficner | first6=Ralf }}
- {{cite journal | author=Ingelfinger D |title=Two protein–protein interaction sites on the spliceosome-associated human cyclophilin CypH |journal=Nucleic Acids Res. |volume=31 |issue= 16 |pages= 4791–6 |year= 2004 |pmid= 12907720 |doi=10.1093/nar/gkg660 | pmc=169899 |name-list-format=vanc| author2=Göthel SF | author3=Marahiel MA | display-authors=3 | last4=Reidt | first4=U | last5=Ficner | first5=R | last6=Lührmann | first6=R | last7=Achsel | first7=T }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |name-list-format=vanc| author2=Lam YW | author3=Leung AK | display-authors=3 | last4=Ong | first4=Shao-En | last5=Lyon | first5=Carol E. | last6=Lamond | first6=Angus I. | last7=Mann | first7=Matthias }}
- {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }}
{{refend}}{{PDB Gallery|geneid=10465}}{{gene-1-stub}} |