| 释义 |
- References
- Further reading
{{Infobox_gene}}Peptidyl-prolyl cis-trans isomerase-like 2 is an enzyme that in humans is encoded by the PPIL2 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene.[2]
}}References1. ^{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP| title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 |date=Dec 1999 | pmid = 10591208 | pmc = | doi = 10.1038/990031 |display-authors=etal}}
2. ^1 {{cite web | title = Entrez Gene: PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23759| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Wang BB, Hayenga KJ, Payan DG, Fisher JM |title=Identification of a nuclear-specific cyclophilin which interacts with the proteinase inhibitor eglin c |journal=Biochem. J. |volume=314 |issue= 1|pages= 313–9 |year= 1996 |pmid= 8660300 |doi= | pmc=1217042 }}
- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Pushkarsky T, Yurchenko V, Vanpouille C, etal |title=Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60 |journal=J. Biol. Chem. |volume=280 |issue= 30 |pages= 27866–71 |year= 2005 |pmid= 15946952 |doi= 10.1074/jbc.M503770200 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Davis TL, Walker JR, Campagna-Slater V, etal |title=Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases |journal=PLoS Biol. |volume=8 |issue= 7 |pages= e1000439 |year= 2010 |pmid= 20676357 |doi= 10.1371/journal.pbio.1000439 | pmc=2911226}}
{{refend}}{{PDB Gallery|geneid=23759}}{{gene-22-stub}} |