| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997).[supplied by OMIM][2]
}}InteractionsPPP1R9B has been shown to interact with PPP1CB,[3] PPP1CA,[3] Dopamine receptor D2,[4] P16,[5] PPP1CC,[3][4] T-cell lymphoma invasion and metastasis-inducing protein 1[6] and PPP1R2.[7] References1. ^{{cite journal |vauthors=Allen PB, Ouimet CC, Greengard P | title = Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 18 | pages = 9956–61 |date=Oct 1997 | pmid = 9275233 | pmc = 23308 | doi =10.1073/pnas.94.18.9956 | bibcode =1997PNAS...94.9956A }}
2. ^1 {{cite web | title = Entrez Gene: PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84687| accessdate = }}
3. ^1 2 {{cite journal |last=Hsieh-Wilson |first=L C |authorlink= |author2=Allen P B |author3=Watanabe T |author4=Nairn A C |author5=Greengard P |date=Apr 1999 |title=Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 |journal=Biochemistry |volume=38 |issue=14 |pages=4365–73 |publisher= |location = UNITED STATES| issn = 0006-2960| pmid = 10194355 |doi = 10.1021/bi982900m | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
4. ^1 {{cite journal |last=Smith |first=F D |authorlink= |author2=Oxford G S |author3=Milgram S L |date=Jul 1999 |title=Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein |journal=J. Biol. Chem. |volume=274 |issue=28 |pages=19894–900 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10391935 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.28.19894 }}
5. ^{{cite journal |last=Vivo |first=M |authorlink= |author2=Calogero R A |author3=Sansone F |author4=Calabrò V |author5=Parisi T |author6=Borrelli L |author7=Saviozzi S |author8=La Mantia G |date=Apr 2001 |title=The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein |journal=J. Biol. Chem. |volume=276 |issue=17 |pages=14161–9 |publisher= |location = United States| issn = 0021-9258| pmid = 11278317 |doi = 10.1074/jbc.M006845200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
6. ^{{cite journal |last=Buchsbaum |first=Rachel J |authorlink= |author2=Connolly Beth A |author3=Feig Larry A |date=May 2003 |title=Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin |journal=J. Biol. Chem. |volume=278 |issue=21 |pages=18833–41 |publisher= |location = United States| issn = 0021-9258| pmid = 12531897 |doi = 10.1074/jbc.M207876200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
7. ^{{cite journal |last=Terry-Lorenzo |first=Ryan T |authorlink= |author2=Elliot Elizabeth |author3=Weiser Douglas C |author4=Prickett Todd D |author5=Brautigan David L |author6=Shenolikar Shirish |date=Nov 2002 |title=Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton |journal=J. Biol. Chem. |volume=277 |issue=48 |pages=46535–43 |publisher= |location = United States| issn = 0021-9258| pmid = 12270929 |doi = 10.1074/jbc.M206960200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Burnett PE, Blackshaw S, Lai MM, etal |title=Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8351–6 |year= 1998 |pmid= 9653190 |doi=10.1073/pnas.95.14.8351 | pmc=20979 |bibcode=1998PNAS...95.8351B }}
- {{cite journal |vauthors=Hsieh-Wilson LC, Allen PB, Watanabe T, etal |title=Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1 |journal=Biochemistry |volume=38 |issue= 14 |pages= 4365–73 |year= 1999 |pmid= 10194355 |doi= 10.1021/bi982900m }}
- {{cite journal |vauthors=Smith FD, Oxford GS, Milgram SL |title=Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein |journal=J. Biol. Chem. |volume=274 |issue= 28 |pages= 19894–900 |year= 1999 |pmid= 10391935 |doi=10.1074/jbc.274.28.19894 }}
- {{cite journal |vauthors=Stephens DJ, Banting G |title=Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30080–6 |year= 1999 |pmid= 10514494 |doi=10.1074/jbc.274.42.30080 }}
- {{cite journal |vauthors=Richman JG, Brady AE, Wang Q, etal |title=Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15003–8 |year= 2001 |pmid= 11154706 |doi= 10.1074/jbc.M011679200 }}
- {{cite journal |vauthors=Vivo M, Calogero RA, Sansone F, etal |title=The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 14161–9 |year= 2001 |pmid= 11278317 |doi= 10.1074/jbc.M006845200 }}
- {{cite journal |vauthors=Grossman SD, Hsieh-Wilson LC, Allen PB, etal |title=The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines |journal=Neuromolecular Med. |volume=2 |issue= 1 |pages= 61–9 |year= 2003 |pmid= 12230305 |doi=10.1385/NMM:2:1:61 }}
- {{cite journal |vauthors=Terry-Lorenzo RT, Elliot E, Weiser DC, etal |title=Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46535–43 |year= 2003 |pmid= 12270929 |doi= 10.1074/jbc.M206960200 }}
- {{cite journal |vauthors=Hsieh-Wilson LC, Benfenati F, Snyder GL, etal |title=Phosphorylation of spinophilin modulates its interaction with actin filaments |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 1186–94 |year= 2003 |pmid= 12417592 |doi= 10.1074/jbc.M205754200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Buchsbaum RJ, Connolly BA, Feig LA |title=Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 18833–41 |year= 2003 |pmid= 12531897 |doi= 10.1074/jbc.M207876200 }}
- {{cite journal |vauthors=Tsukada M, Prokscha A, Oldekamp J, Eichele G |title=Identification of neurabin II as a novel doublecortin interacting protein |journal=Mech. Dev. |volume=120 |issue= 9 |pages= 1033–43 |year= 2004 |pmid= 14550532 |doi=10.1016/S0925-4773(03)00177-1 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Law AJ, Weickert CS, Hyde TM, etal |title=Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines |journal=The American Journal of Psychiatry |volume=161 |issue= 10 |pages= 1848–55 |year= 2004 |pmid= 15465982 |doi= 10.1176/appi.ajp.161.10.1848 }}
{{refend}}{{PDB Gallery|geneid=84687}}{{gene-17-stub}} |