1. Function

2. Interactions

3. References

4. Further reading

Function

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

PPP2R1B has been shown to interact with:

• PPP2CA,^[5][6]
• PPP2CB,^[5]
• PPP2R2A,^[5][4]
• PPP2R3B,^[5]
• PPP2R5A,^[5][6][13]
• PPP2R5B,^[13]
• PPP2R5C,^[13]
• PPP2R5D,^[13] and
• PPP2R5E.^[7]

References

Further reading

• {{cite journal | vauthors = Zolnierowicz S | title = Type 2A protein phosphatase, the complex regulator of numerous signaling pathways | journal = Biochemical Pharmacology | volume = 60 | issue = 8 | pages = 1225–35 | date = Oct 2000 | pmid = 11007961 | doi = 10.1016/S0006-2952(00)00424-X }}
• {{cite journal | vauthors = Kamibayashi C, Lickteig RL, Estes R, Walter G, Mumby MC | title = Expression of the A subunit of protein phosphatase 2A and characterization of its interactions with the catalytic and regulatory subunits | journal = The Journal of Biological Chemistry | volume = 267 | issue = 30 | pages = 21864–72 | date = Oct 1992 | pmid = 1328247 | doi = }}
• {{cite journal | vauthors = Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R | title = Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr | journal = FEBS Letters | volume = 401 | issue = 2-3 | pages = 197–201 | date = Jan 1997 | pmid = 9013886 | doi = 10.1016/S0014-5793(96)01470-6 }}
• {{cite journal | vauthors = Adler HT, Nallaseth FS, Walter G, Tkachuk DC | title = HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A | journal = The Journal of Biological Chemistry | volume = 272 | issue = 45 | pages = 28407–14 | date = Nov 1997 | pmid = 9353299 | doi = 10.1074/jbc.272.45.28407 }}
• {{cite journal | vauthors = Ruediger R, Brewis N, Ohst K, Walter G | title = Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production | journal = Virology | volume = 238 | issue = 2 | pages = 432–43 | date = Nov 1997 | pmid = 9400615 | doi = 10.1006/viro.1997.8873 }}
• {{cite journal | vauthors = Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J, Evans GA | title = Alterations of the PPP2R1B gene in human lung and colon cancer | journal = Science | volume = 282 | issue = 5387 | pages = 284–7 | date = Oct 1998 | pmid = 9765152 | doi = 10.1126/science.282.5387.284 }}
• {{cite journal | vauthors = Takahashi M, Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y | title = Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus | journal = The Journal of Biological Chemistry | volume = 274 | issue = 24 | pages = 17267–74 | date = Jun 1999 | pmid = 10358086 | doi = 10.1074/jbc.274.24.17267 }}
• {{cite journal | vauthors = Campbell IG, Manolitsas T | title = Absence of PPP2R1B gene alterations in primary ovarian cancers | journal = Oncogene | volume = 18 | issue = 46 | pages = 6367–9 | date = Nov 1999 | pmid = 10597236 | doi = 10.1038/sj.onc.1203070 }}
• {{cite journal | vauthors = Takagi Y, Futamura M, Yamaguchi K, Aoki S, Takahashi T, Saji S | title = Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers | journal = Gut | volume = 47 | issue = 2 | pages = 268–71 | date = Aug 2000 | pmid = 10896920 | pmc = 1727986 | doi = 10.1136/gut.47.2.268 }}
• {{cite journal | vauthors = Baysal BE, Willett-Brozick JE, Taschner PE, Dauwerse JG, Devilee P, Devlin B | title = A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region | journal = European Journal of Human Genetics | volume = 9 | issue = 2 | pages = 121–9 | date = Feb 2001 | pmid = 11313745 | doi = 10.1038/sj.ejhg.5200585 }}
• {{cite journal | vauthors = Ruediger R, Pham HT, Walter G | title = Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene | journal = Oncogene | volume = 20 | issue = 15 | pages = 1892–9 | date = Apr 2001 | pmid = 11313937 | doi = 10.1038/sj.onc.1204279 }}
• {{cite journal | vauthors = Yokoyama N, Reich NC, Miller WT | title = Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway | journal = Journal of Interferon & Cytokine Research | volume = 21 | issue = 6 | pages = 369–78 | date = Jun 2001 | pmid = 11440634 | doi = 10.1089/107999001750277844 }}
• {{cite journal | vauthors = Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y | title = HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 | journal = Virology | volume = 287 | issue = 2 | pages = 359–70 | date = Sep 2001 | pmid = 11531413 | doi = 10.1006/viro.2001.1007 }}
• {{cite journal | vauthors = Yang J, Fan GH, Wadzinski BE, Sakurai H, Richmond A | title = Protein phosphatase 2A interacts with and directly dephosphorylates RelA | journal = The Journal of Biological Chemistry | volume = 276 | issue = 51 | pages = 47828–33 | date = Dec 2001 | pmid = 11591705 | pmc = 2665282 | doi = 10.1074/jbc.M106103200 }}
• {{cite journal | vauthors = Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT | title = Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits | journal = The Journal of Biological Chemistry | volume = 277 | issue = 23 | pages = 20750–5 | date = Jun 2002 | pmid = 11929880 | doi = 10.1074/jbc.M202992200 }}
• {{cite journal | vauthors = Hemmer S, Wasenius VM, Haglund C, Zhu Y, Knuutila S, Franssila K, Joensuu H | title = Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas | journal = Cancer Genetics and Cytogenetics | volume = 134 | issue = 1 | pages = 13–7 | date = Apr 2002 | pmid = 11996789 | doi = 10.1016/S0165-4608(01)00597-0 }}

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