“PPP2R5B”的意思、由来-开放百科全书

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily.^[2]

References

1. ^{{cite journal | vauthors = McCright B, Virshup DM | title = Identification of a new family of protein phosphatase 2A regulatory subunits | journal = The Journal of Biological Chemistry | volume = 270 | issue = 44 | pages = 26123–8 | date = Nov 1995 | pmid = 7592815 | pmc = | doi = 10.1074/jbc.270.44.26123 }}
2. ^¹{{cite web | title = Entrez Gene: PPP2R5B protein phosphatase 2, regulatory subunit B', beta isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5526| accessdate = }}
3. ^¹{{cite journal | vauthors = McCright B, Rivers AM, Audlin S, Virshup DM | title = The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm | journal = The Journal of Biological Chemistry | volume = 271 | issue = 36 | pages = 22081–9 | date = Sep 1996 | pmid = 8703017 | doi = 10.1074/jbc.271.36.22081 }}
4. ^{{cite journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Molecular & Cellular Proteomics | volume = 8 | issue = 1 | pages = 157–71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 }}

Further reading

{{cite journal | vauthors = Le Rouzic E, Benichou S | title = The Vpr protein from HIV-1: distinct roles along the viral life cycle | journal = Retrovirology | volume = 2 | issue = | pages = 11 | year = 2006 | pmid = 15725353 | pmc = 554975 | doi = 10.1186/1742-4690-2-11 }}

{{cite journal | vauthors = Zhao RY, Elder RT | title = Viral infections and cell cycle G2/M regulation | journal = Cell Research | volume = 15 | issue = 3 | pages = 143–9 | date = Mar 2005 | pmid = 15780175 | doi = 10.1038/sj.cr.7290279 }}

{{cite journal | vauthors = Zhao RY, Bukrinsky M, Elder RT | title = HIV-1 viral protein R (Vpr) & host cellular responses | journal = The Indian Journal of Medical Research | volume = 121 | issue = 4 | pages = 270–86 | date = Apr 2005 | pmid = 15817944 | doi = }}

{{cite journal | vauthors = Cross SH, Charlton JA, Nan X, Bird AP | title = Purification of CpG islands using a methylated DNA binding column | journal = Nature Genetics | volume = 6 | issue = 3 | pages = 236–44 | date = Mar 1994 | pmid = 8012384 | doi = 10.1038/ng0394-236 }}

{{cite journal | vauthors = Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA | title = The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits | journal = The Biochemical Journal | volume = 317 | issue = 1 | pages = 187–94 | date = Jul 1996 | pmid = 8694763 | pmc = 1217462 | doi = 10.1042/bj3170187}}

{{cite journal | vauthors = McCright B, Rivers AM, Audlin S, Virshup DM | title = The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm | journal = The Journal of Biological Chemistry | volume = 271 | issue = 36 | pages = 22081–9 | date = Sep 1996 | pmid = 8703017 | doi = 10.1074/jbc.271.36.22081 }}

{{cite journal | vauthors = McCright B, Brothman AR, Virshup DM | title = Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12 | journal = Genomics | volume = 36 | issue = 1 | pages = 168–70 | date = Aug 1996 | pmid = 8812429 | doi = 10.1006/geno.1996.0438 }}

{{cite journal | vauthors = Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R | title = Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr | journal = FEBS Letters | volume = 401 | issue = 2–3 | pages = 197–201 | date = Jan 1997 | pmid = 9013886 | doi = 10.1016/S0014-5793(96)01470-6 }}

{{cite journal | vauthors = Forbes SA, Pannett AA, Bassett JH, Harding B, Wooding C, Thakker RV, Butler R, Ogilvie D, Anand R, Gaudray P, Weber G, Larsson C, Zhang CX, Calender A, Höppener JW, Lips CJ, Kas K | title = Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1) | journal = Human Genetics | volume = 100 | issue = 3–4 | pages = 481–5 | date = Sep 1997 | pmid = 9272177 | doi = 10.1007/s004390050538 }}

{{cite journal | vauthors = Ruediger R, Brewis N, Ohst K, Walter G | title = Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production | journal = Virology | volume = 238 | issue = 2 | pages = 432–43 | date = Nov 1997 | pmid = 9400615 | doi = 10.1006/viro.1997.8873 }}

{{cite journal | vauthors = Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A | title = GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin | journal = Oncogene | volume = 19 | issue = 4 | pages = 537–45 | date = Jan 2000 | pmid = 10698523 | doi = 10.1038/sj.onc.1203359 }}

{{cite journal | vauthors = Hrimech M, Yao XJ, Branton PE, Cohen EA | title = Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A | journal = The EMBO Journal | volume = 19 | issue = 15 | pages = 3956–67 | date = Aug 2000 | pmid = 10921877 | pmc = 306605 | doi = 10.1093/emboj/19.15.3956 }}{{Retracted|intentional=yes}}

{{cite journal | vauthors = Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y | title = HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 | journal = Virology | volume = 287 | issue = 2 | pages = 359–70 | date = Sep 2001 | pmid = 11531413 | doi = 10.1006/viro.2001.1007 }}

{{cite journal | vauthors = Hrimech M, Yao XJ, Branton PE, Cohen EA | title = Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A | journal = The EMBO Journal | volume = 21 | issue = 14 | pages = 3918 | date = Jul 2002 | pmid = 12110603 | pmc = 126131 | doi = 10.1093/emboj/cdf420 }}

{{cite journal | vauthors = Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A | title = Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes | journal = Journal of Neurovirology | volume = 9 | issue = 3 | pages = 358–71 | date = Jun 2003 | pmid = 12775419 | doi = 10.1080/13550280390201119 }}

{{cite journal | vauthors = Dozier C, Bonyadi M, Baricault L, Tonasso L, Darbon JM | title = Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit | journal = Biology of the Cell / Under the Auspices of the European Cell Biology Organization | volume = 96 | issue = 7 | pages = 509–17 | date = Sep 2004 | pmid = 15380617 | doi = 10.1016/j.biolcel.2004.04.010 }}

Function

Interactions

References

Further reading