1. Function

2. Interactions

3. References

4. Further reading

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily.^[2]

Interactions

PPP2R5E has been shown to interact with PPP2R1B^[3] and PPP2CA.^[3][4]

References

Further reading

• {{cite journal | vauthors = Le Rouzic E, Benichou S | title = The Vpr protein from HIV-1: distinct roles along the viral life cycle | journal = Retrovirology | volume = 2 | issue = | pages = 11 | year = 2006 | pmid = 15725353 | pmc = 554975 | doi = 10.1186/1742-4690-2-11 }}
• {{cite journal | vauthors = Zhao RY, Elder RT | title = Viral infections and cell cycle G2/M regulation | journal = Cell Research | volume = 15 | issue = 3 | pages = 143–9 | date = Mar 2005 | pmid = 15780175 | doi = 10.1038/sj.cr.7290279 }}
• {{cite journal | vauthors = Zhao RY, Bukrinsky M, Elder RT | title = HIV-1 viral protein R (Vpr) & host cellular responses | journal = The Indian Journal of Medical Research | volume = 121 | issue = 4 | pages = 270–86 | date = Apr 2005 | pmid = 15817944 | doi = }}
• {{cite journal | vauthors = Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA | title = The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits | journal = The Biochemical Journal | volume = 317 | issue = Pt 1 | pages = 187–94 | date = Jul 1996 | pmid = 8694763 | pmc = 1217462 | doi = 10.1042/bj3170187}}
• {{cite journal | vauthors = McCright B, Rivers AM, Audlin S, Virshup DM | title = The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm | journal = The Journal of Biological Chemistry | volume = 271 | issue = 36 | pages = 22081–9 | date = Sep 1996 | pmid = 8703017 | doi = 10.1074/jbc.271.36.22081 }}
• {{cite journal | vauthors = McCright B, Brothman AR, Virshup DM | title = Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12 | journal = Genomics | volume = 36 | issue = 1 | pages = 168–70 | date = Aug 1996 | pmid = 8812429 | doi = 10.1006/geno.1996.0438 }}
• {{cite journal | vauthors = Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R | title = Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr | journal = FEBS Letters | volume = 401 | issue = 2–3 | pages = 197–201 | date = Jan 1997 | pmid = 9013886 | doi = 10.1016/S0014-5793(96)01470-6 }}
• {{cite journal | vauthors = Ruediger R, Brewis N, Ohst K, Walter G | title = Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production | journal = Virology | volume = 238 | issue = 2 | pages = 432–43 | date = Nov 1997 | pmid = 9400615 | doi = 10.1006/viro.1997.8873 }}
• {{cite journal | vauthors = Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y | title = HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 | journal = Virology | volume = 287 | issue = 2 | pages = 359–70 | date = Sep 2001 | pmid = 11531413 | doi = 10.1006/viro.2001.1007 }}
• {{cite journal | vauthors = Hrimech M, Yao XJ, Branton PE, Cohen EA | title = Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A | journal = The EMBO Journal | volume = 21 | issue = 14 | pages = 3918 | date = Jul 2002 | pmid = 12110603 | pmc = 126131 | doi = 10.1093/emboj/cdf420 }}
• {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
• {{cite journal | vauthors = Dozier C, Bonyadi M, Baricault L, Tonasso L, Darbon JM | title = Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit | journal = Biology of the Cell / Under the Auspices of the European Cell Biology Organization | volume = 96 | issue = 7 | pages = 509–17 | date = Sep 2004 | pmid = 15380617 | doi = 10.1016/j.biolcel.2004.04.010 }}
• {{cite journal | vauthors = Ammosova T, Washington K, Debebe Z, Brady J, Nekhai S | title = Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription | journal = Retrovirology | volume = 2 | issue = | pages = 47 | year = 2006 | pmid = 16048649 | pmc = 1187922 | doi = 10.1186/1742-4690-2-47 }}

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