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词条 PPP3CC
释义

  1. References

  2. Further reading

{{Underlinked|date=September 2017}}{{Infobox_gene}}Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM][2]
}}

References

1. ^{{cite journal |vauthors=Muramatsu T, Kincaid RL | title = Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A) | journal = Biochem Biophys Res Commun | volume = 188 | issue = 1 | pages = 265–71 |date=Nov 1992 | pmid = 1339277 | pmc = | doi =10.1016/0006-291X(92)92379-C }}
2. ^{{cite web | title = Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5533| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal | author=Esau C |title=Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells |journal=J. Exp. Med. |volume=194 |issue= 10 |pages= 1449–59 |year= 2001 |pmid= 11714752 |doi=10.1084/jem.194.10.1449 | pmc=2193671 |name-list-format=vanc| author2=Boes M | author3=Youn HD | display-authors=3 | last4=Tatterson | first4=L | last5=Liu | first5=JO | last6=Chen | first6=J }}
  • {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
  • {{cite journal |vauthors=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha |journal=Virology |volume=303 |issue= 1 |pages= 174–80 |year= 2003 |pmid= 12482669 |doi=10.1006/viro.2002.1676 }}
  • {{cite journal | author=Gerber DJ |title=Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 8993–8 |year= 2003 |pmid= 12851458 |doi= 10.1073/pnas.1432927100 | pmc=166426 |name-list-format=vanc| author2=Hall D | author3=Miyakawa T | display-authors=3 | last4=Demars | first4=S | last5=Gogos | first5=JA | last6=Karayiorgou | first6=M | last7=Tonegawa | first7=S }}
  • {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}
  • {{cite journal | author=Barrios-Rodiles M |title=High-throughput mapping of a dynamic signaling network in mammalian cells |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |name-list-format=vanc| author2=Brown KR | author3=Ozdamar B | display-authors=3 | last4=Bose | first4=R | last5=Liu | first5=Z | last6=Donovan | first6=RS | last7=Shinjo | first7=F | last8=Liu | first8=Y | last9=Dembowy | first9=J }}
  • {{cite journal |vauthors=Eastwood SL, Burnet PW, Harrison PJ |title=Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia |journal=Biol. Psychiatry |volume=57 |issue= 7 |pages= 702–10 |year= 2005 |pmid= 15820226 |doi= 10.1016/j.biopsych.2004.12.029 }}
  • {{cite journal | author=Kinoshita Y |title=No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia |journal=Journal of Neural Transmission |volume=112 |issue= 9 |pages= 1255–62 |year= 2006 |pmid= 15843870 |doi= 10.1007/s00702-004-0261-5 |name-list-format=vanc| author2=Suzuki T | author3=Ikeda M | display-authors=3 | last4=Kitajima | first4=T. | last5=Yamanouchi | first5=Y. | last6=Inada | first6=T. | last7=Yoneda | first7=H. | last8=Iwata | first8=N. | last9=Ozaki | first9=N. }}
  • {{cite journal | author=Liu YL |title=More evidence supports the association of PPP3CC with schizophrenia |journal=Mol. Psychiatry |volume=12 |issue= 10 |pages= 966–74 |year= 2008 |pmid= 17339875 |doi= 10.1038/sj.mp.4001977 |name-list-format=vanc| author2=Fann CS | author3=Liu CM | display-authors=3 | last4=Chang | first4=C C | last5=Yang | first5=W C | last6=Hung | first6=S I | last7=Yu | first7=S L | last8=Hwang | first8=T J | last9=Hsieh | first9=M H }}
  • {{cite journal | author=Horiuchi Y |title=Support for association of the PPP3CC gene with schizophrenia |journal=Mol. Psychiatry |volume=12 |issue= 10 |pages= 891–3 |year= 2008 |pmid= 17895921 |doi= 10.1038/sj.mp.4002019 |name-list-format=vanc| author2=Ishiguro H | author3=Koga M | display-authors=3 | last4=Inada | first4=T | last5=Iwata | first5=N | last6=Ozaki | first6=N | last7=Ujike | first7=H | last8=Muratake | first8=T | last9=Someya | first9=T }}
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